机构

• 上海药物研究所 [18]
• 上海生物化学与细胞生... [5]
• 化学研究所 [2]
• 昆明植物研究所 [2]
• 海洋研究所 [2]
• 生态环境研究中心 [2]
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采集方式

• OAI收割 [46]

内容类型

• 期刊论文 [45]
• 学位论文 [1]

发表日期

• 2024 [2]
• 2023 [1]
• 2022 [3]
• 2021 [2]
• 2020 [3]
• 2019 [3]
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学科主题

• Biochemist... [3]
• Biochemist... [1]
• Biochemist... [1]
• Biophysics [1]
• Developmen... [1]
• Immunology [1]
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浏览/检索结果: 共46条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Interaction-Based Inductive Bias in Graph Neural Networks: Enhancing Protein-Ligand Binding Affinity Predictions From 3D Structures 期刊论文  OAI收割 IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE, 2024, 卷号: 46, 期号: 12, 页码: 8191-8208 作者:  Yang, Ziduo;  Zhong, Weihe;  Lv, Qiujie;  Dong, Tiejun;  Chen, Guanxing   |  收藏  |  浏览/下载：12/0  |  提交时间：2025/01/14 Proteins  Programmable logic arrays  Three-dimensional displays  Predictive models  Graph neural networks  Data models  Convolution  Protein-ligand binding affinity  graph neural networks  inductive bias  drug-target interaction  structure-based virtual screening   Substrate and Functional Diversity of Protein Lysine Post-translational Modifications 期刊论文  OAI收割 GENOMICS PROTEOMICS & BIOINFORMATICS, 2024, 卷号: 22, 期号: 1, 页码: 21 作者:  Hao, Bingbing;  Chen, Kaifeng;  Zhai, Linhui;  Liu, Muyin;  Liu, Bin   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/12/16 Protein lysine PTM  Regulatory enzyme  PTM crosstalk  Drug target  Acylation   Molecular dynamics study on the behavior and binding mechanism of target protein Transgelin-2 with its agonist TSG12 for anti-asthma drug discovery 期刊论文  OAI收割 COMPUTERS IN BIOLOGY AND MEDICINE, 2023, 卷号: 153, 页码: 7 作者:  Wu, Leyun;  Wang, Guangpu;  Zhou, Liping;  Mo, Mengxia;  Shi, Yulong   |  收藏  |  浏览/下载：44/0  |  提交时间：2023/04/10 Pharmaceutical sciences  Molecular dynamics simulation  Free energy calculation  Asthma  Target protein  Transgelin-2  Agonist   Proteomic characterization of post-translational modifications in drug discovery 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 18 作者:  Zhai, Lin-hui;  Chen, Kai-feng;  Hao, Bing-bing;  Tan, Min-jia   |  收藏  |  浏览/下载：25/0  |  提交时间：2023/04/10 proteomics  protein post-translational modification  drug target  off-target  drug mechanism  precision medicine   Bile acid and receptors: biology and drug discovery for nonalcoholic fatty liver disease 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 17 作者:  Jiao, Ting-ying;  Ma, Yuan-di;  Guo, Xiao-zhen;  Ye, Yun-fei;  Xie, Cen   |  收藏  |  浏览/下载：33/0  |  提交时间：2022/06/15 bile acids  nonalcoholic fatty liver disease  nonalcoholic steatohepatitis  drug target  Farnesoid X receptor  G protein-coupled bile acid receptor   Small molecule QF84139 ameliorates cardiac hypertrophy via activating the AMPK signaling pathway 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 卷号: 43, 期号: 3, 页码: 588-601 作者:  Li,Xu-xia;  Zhang,Peng;  Yang,Yang;  Wang,Jing-jing;  Zheng,Yan-jun   |  收藏  |  浏览/下载：41/0  |  提交时间：2022/04/02 cardiac hypertrophy  pyrazine derivative  QF84139  phenylephrine  transverse aortic constriction  AMPK signaling pathway  PROTEIN-KINASE  MAMMALIAN TARGET  OVERLOAD  METFORMIN  MACROPHAGES  MECHANISMS  MEDICINE  ALPHA  CELLS  MODEL   The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review 期刊论文  OAI收割 MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021, 卷号: 21, 期号: 7, 页码: 803-815 作者:  Zhang, Jiajia;  Wu, Ning;  Shi, Dayong   |  收藏  |  浏览/下载：30/0  |  提交时间：2021/05/11 Signaling pathway  mammalian target of rapamycin  protein tyrosine phosphatase 1b  dipeptidase 4  cancer  diabetes  pharmacology  target compounds   Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 104963 作者:  Liu,Jiangxin;  Wu,Xing-De;  Li,Wenyan;  Yuan,Zaifeng;  Yang,Kun   |  收藏  |  浏览/下载：26/0  |  提交时间：2022/04/02 Pseudolaric acid A  Hsp90 inhibitor  Apoptosis  NMR  Structure-activity relationship  Photoaffinity-based probe  Protein-ligand interaction  MOLECULAR CHAPERONE  PROTEIN  TARGET  CANCER  KINASE  NMR  IDENTIFICATION  SELECTIVITY  BINDING  DESIGN   FoxP3 in T-reg cell biology: a molecular and structural perspective 期刊论文  OAI收割 CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2020, 卷号: 199, 期号: 3, 页码: 255-262 作者:  Deng, G.;  Song, X.;  Greene, M. I.;  ,   |  收藏  |  浏览/下载：19/0  |  提交时间：2020/12/21 TRANSCRIPTION FACTOR FOXP3  TARGET GENES  PROTEIN  STABILITY  DOMAIN  ALPHA  DIFFERENTIATION  TRANSPLANTATION  AUTOIMMUNITY  DEACETYLASES   Caffeic Acid Phenethyl Ester Effects: In Silico Study of its Osteoimmunological Mechanisms 期刊论文  OAI收割 LETTERS IN DRUG DESIGN & DISCOVERY, 2020, 卷号: 17, 期号: 5, 页码: 556-562 作者:  Zhao, Yuhao;  Pang, Xiaokun;  Nepal, Akriti;  Jiang, Xincan;  Xu, Xiaoxin   |  收藏  |  浏览/下载：33/0  |  提交时间：2020/06/22 Drug target  drug-protein interaction  in silico prediction  osteoimmunological  PASS prediction  CAPE