机构

• 上海药物研究所 [14]
• 地理科学与资源研究所 [3]
• 金属研究所 [2]
• 大连化学物理研究所 [2]
• 数学与系统科学研究院 [1]
• 生态环境研究中心 [1]
• 更多

采集方式

• OAI收割 [23]

内容类型

• 期刊论文 [23]

发表日期

• 2025 [2]
• 2024 [1]
• 2023 [2]
• 2021 [1]
• 2019 [4]
• 2017 [1]
• 更多

学科主题

筛选

浏览/检索结果: 共23条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 Design, synthesis, and biological evaluation of thioamide-linked spiropyrrolidine derivatives as novel 3CLpro inhibitors against SARS-CoV-2 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 11 作者:  Guma, Samuel Desta;  Song, Kang;  Sun, Haiguo;  Yang, Lei;  Zhou, Zhaoyin   |  收藏  |  浏览/下载：2/0  |  提交时间：2025/08/20 SARS-CoV-2  3CL(pro) inhibitors  Thioamide derivatives  Spiropyrrolidine derivatives  Nirmatrelvir  HCoV-OC43  Antiviral  Metabolic stability   One stone two birds: Introducing piperazine into a series of nucleoside derivatives as potent and selective PRMT5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 281, 页码: 18 作者:  Li, Huaxuan;  Yang, Hong;  Liu, Li;  Zheng, Jiahong;  Shi, Qiongyu   |  收藏  |  浏览/下载：36/0  |  提交时间：2024/12/11 Protein arginine methyltransferase 5  Nucleoside derivatives  Piperazine  Metabolic stability  Symmetric dimethylarginines   Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 10 作者:  Chen, Guofeng;  Xie, Hang;  Liu, Jiayuan;  Shao, Qiang;  Li, Minjun   |  收藏  |  浏览/下载：34/0  |  提交时间：2024/01/26 Methyl substitution  Selectivity  FABP4 inhibitor  Anti-inflammation  Metabolic stability   Exploration of novel four-membered-heterocycle constructed peptidyl proteasome inhibitors with improved metabolic stability for cancer treatment 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 138, 页码: 22 作者:  Wang, Hanlin;  Wu, Zhaoxiao;  Cao, Yu;  Gao, Lixin;  Shao, Jiaan   |  收藏  |  浏览/下载：52/0  |  提交时间：2023/10/17 Metabolic stability  Four-membered heterocycles  Proteasome inhibitors  Multiple myeloma   Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 251, 页码: 115213 作者:  Sun, Nannan;  Yu, Mingcheng;  Jiang, Zhengyuan   |  收藏  |  浏览/下载：30/0  |  提交时间：2024/03/27 ROR?t agonists  Carbazole carboxamide  Agonistic activity  Metabolic stability  Co-crystallization  Molecular docking   Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14 作者:  He, Yu-Long;  Chen, Meng-Ting;  Wang, Ting;  Zhang, Ming-Ming;  Li, Ying-Xia   |  收藏  |  浏览/下载：74/0  |  提交时间：2021/11/04 Type 2 diabetes mellitus  Dual FABP4/5 inhibitors  Anti-lipolytic and anti-inflammatory effects  Metabolic stability  Anti-diabetic activities   Research on the synergy of urban system operation-Based on the perspective of urban metabolism 期刊论文  OAI收割 SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 卷号: 662, 页码: 446-454 作者:  Fan, Yupeng;  Fang, Chuanglin   |  收藏  |  浏览/下载：69/0  |  提交时间：2019/05/22 Urban metabolic system  Sustainable development  Mutualism  Competition  Synergism  Stability   Research on the synergy of urban system operation-Based on the perspective of urban metabolism 期刊论文  OAI收割 SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 卷号: 662, 页码: 446-454 作者:  Fan, Yupeng;  Fang, Chuanglin   |  收藏  |  浏览/下载：27/0  |  提交时间：2019/05/22 Urban metabolic system  Sustainable development  Mutualism  Competition  Synergism  Stability   Research on the synergy of urban system operation-Based on the perspective of urban metabolism 期刊论文  OAI收割 SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 卷号: 662, 页码: 446-454 作者:  Fan, Yupeng;  Fang, Chuanglin   |  收藏  |  浏览/下载：34/0  |  提交时间：2019/05/22 Urban metabolic system  Sustainable development  Mutualism  Competition  Synergism  Stability   Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 423-439 作者:  Yu, Jianjun;  Liu, Jieyu;  Li, Daqiang;  Xu, Lei;  Hong, Duidui   |  收藏  |  浏览/下载：47/0  |  提交时间：2020/07/01 Proteasome inhibitors  Macrocyclic dipeptides  N-Benzyl amides  Metabolic stability