机构

• 上海药物研究所 [7]
• 大连化学物理研究所 [2]
• 长春应用化学研究所 [1]

采集方式

• OAI收割 [10]

内容类型

• 期刊论文 [10]

发表日期

• 2024 [1]
• 2023 [1]
• 2021 [1]
• 2019 [1]
• 2016 [2]
• 2015 [1]
• 更多

学科主题

筛选

浏览/检索结果: 共10条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Structure-based development of potent and selective type-II kinase inhibitors of RIPK1 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334 作者:  Qin, Ying;  Li, Dekang;  Qi, Chunting;  Xiang, Huaijiang;  Meng, Huyan   |  收藏  |  浏览/下载：23/0  |  提交时间：2024/03/06 RIPK1  Necroptosis  Type-II kinase inhibitors  Rational design  Lead optimization  Structure-activity relationship  Anti-inflammation  Preclinical drug discovery   Development of PI3Kγ selective inhibitors: the strategies and application 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 10 作者:  Gu, Dong-Yan;  Zhang, Meng-Meng;  Li, Jia;  Zhou, Yu-Bo;  Sheng, Rong   |  收藏  |  浏览/下载：21/0  |  提交时间：2023/12/08 PI3K  PI3K gamma inhibitors  isoform selectivity  drug development  rational drug design   Drug design targeting active posttranslational modification protein isoforms 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2021, 卷号: 41, 期号: 3, 页码: 1701-1750 作者:  Meng, Fanwang;  Liang, Zhongjie;  Zhao, Kehao;  Luo, Cheng   |  收藏  |  浏览/下载：29/0  |  提交时间：2024/03/22 Allosteric Inhibitor  Covalent Inhibitor  Posttranslational Modifications  Precision Medicine  Protac Protein Degradation  Protein‐  Protein Interactions  Ptm Protein Isoforms  Rational Drug Design   Allostery in Drug Development 期刊论文  OAI收割 PROTEIN ALLOSTERY IN DRUG DISCOVERY, 2019, 卷号: 1163, 页码: 1-23 作者:  Cheng, Xi;  Jiang, Hualiang   |  收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01 Allosteric perturbation  Biased agonists  Conformational changes  Protein dynamics  Rational drug design   Design, synthesis and biological evaluation of bisabolangelone oxime derivatives as potassium-competitive acid blockers (P-CABs) 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 9, 页码: 2268-2272 作者:  Wang, Wen-Bin;  Huang, Nian-Yu;  Chen, Lei;  Luo, Hua-Jun;  Wang, Jun-Zhi   |  收藏  |  浏览/下载：26/0  |  提交时间：2019/06/20 P-cabs  Bisabolangelone  Drug Rational Design  Synthesis  H++  k+-atpase Inhibitory Activities   e-Science Platform Construction Accelerates the Development of Rational Drug Design 期刊论文  OAI收割 Bulletin of the Chinese Academy of Sciences, 2016, 卷号: 31, 期号: 6, 页码: 624-638 作者:  Hu Junchi;  Xu Pan;  Chen Yantao;  Liu Tingting;  Lu Dong   |  收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 e-Science  rational drug design  computer-aided drug design   Androgen receptor: structure, role in prostate cancer and drug discovery 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 1, 页码: 3-23 作者:  Tan, M. H. Eileen;  Li, Jun;  Xu, H. Eric;  Melcher, Karsten;  Yong, Eu-leong   |  收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08 androgen  androgen receptor  prostate cancer  nuclear receptor  drug discovery  rational drug design  structural biology  castration resistance  antiandrogen   Preclinical Evaluation of Antitumor Activity of Acid-Sensitive PEGylated Doxorubicin 期刊论文  OAI收割 acs applied materials & interfaces, 2014, 卷号: 6, 期号: 23, 页码: 21202-21214 Sun, Diankui; Ding, Jianxun; Xiao, Chunsheng; Chen,Jinjin; Zhuang,Xiuli; Chen,Xuesi 收藏  |  浏览/下载：36/0  |  提交时间：2015/06/09 INTRACELLULAR DRUG-DELIVERY  CANCER-THERAPY  POLYPEPTIDE NANOGELS  POLYMERIC MICELLES  TARGETED DELIVERY  RATIONAL DESIGN  IN-VITRO  PH  NANOPARTICLES  ANTICANCER   Non-Covalent Interactions with Aromatic Rings: Current Understanding and Implications for Rational Drug Design 期刊论文  OAI收割 CURRENT PHARMACEUTICAL DESIGN, 2013, 卷号: 19, 期号: 36, 页码: 6522-6533 作者:  Li, Shanshan;  Xu, Yuan;  Shen, Qiancheng;  Liu, Xian;  Lu, Jing   |  收藏  |  浏览/下载：33/0  |  提交时间：2019/01/08 pi-pi interactions  cation-pi interactions  anion-pi interactions  quantum mechanical calculations  crystallographic data mining  rational drug design  Acetylcholine esterase (AChE)  HMG-CoA reductase (HMGR)  serine protease factor Xa (fXa)   Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative 期刊论文  OAI收割 international journal of biological macromolecules, 2011, 卷号: 49, 期号: 5, 页码: 1173-1176 作者:  Zhang, Zhenjiang;  He, Xiangwei;  Yuan, Gu 收藏  |  浏览/下载：12/0  |  提交时间：2015/11/12 G-quadruplex  c-myc  Pyrene derivatives  Rational drug design  Transcription control