机构

• 上海药物研究所 [10]

采集方式

• OAI收割 [10]

内容类型

• 期刊论文 [10]

发表日期

• 2023 [10]

学科主题

筛选

浏览/检索结果: 共10条，第1-10条 帮助 限定条件 发表日期：2023     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：28/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   Discovery of a highly potent NPAS3 heterodimer inhibitor by covalently modifying ARNT 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 139, 页码: 10 作者:  Li, Peizhuo;  Tian, Yucheng;  Shang, Qinghong;  Tang, Cailing;  Hou, Zeng   |  收藏  |  浏览/下载：21/0  |  提交时间：2023/10/17 NPAS3  Covalent inhibitor  Protein -protein interaction  5-nitrothiazole warhead   Discovery and Structural Optimization of Covalent ZAP-70 Kinase Inhibitors against Psoriasis 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 15 作者:  Rao, Danni;  Yang, Tao;  Feng, Huixu;  An, Qi;  Zhang, Shaofeng   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17 Discovery of a New-Generation S-Adenosylmethionine-Noncompetitive Covalent Inhibitor Targeting the Lysine Methyltransferase Enhancer of Zeste Homologue 2 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 11, 页码: 7629-7644 作者:  Zhang, Yi;  Yang, Hong;  Li, Bingbing;  Li, Jiayi;  Li, Huaxuan   |  收藏  |  浏览/下载：20/0  |  提交时间：2023/10/17 Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 10, 页码: 15 作者:  Wang, Qian;  Chen, Guofeng;  He, Jian;  Li, Jiameng;  Xiong, Muya   |  收藏  |  浏览/下载：18/0  |  提交时间：2023/10/17 SARS-CoV-2  papain-like protease  covalent inhibitor  co-crystal structure  in vitro assay   Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches 期刊论文  OAI收割 CHEMICAL SCIENCE, 2023, 卷号: 14, 期号: 18, 页码: 4681-4696 作者:  Shao, Qiang;  Xiong, Muya;  Li, Jiameng;  Hu, Hangchen;  Su, Haixia   |  收藏  |  浏览/下载：0/0  |  提交时间：2024/03/27 Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 5, 页码: 3226-3249 作者:  Li, Chunpu;  Dai, Yang;  Kong, Xiangtai;  Wang, Bao;  Peng, Xia   |  收藏  |  浏览/下载：2/0  |  提交时间：2024/03/27 Covalent inhibitor targets KRasG12C: A new paradigm for drugging the undruggable and challenges ahead 期刊论文  OAI收割 GENES & DISEASES, 2023, 卷号: 10, 期号: 2, 页码: 403-414 作者:  Li, Hui-yu;  Qi, Wei-liang;  Wang, Yu-xiang;  Meng, Ling-hua   |  收藏  |  浏览/下载：117/0  |  提交时间：2023/10/17 Biomarkers  Covalent KRasG12Cinhibitors  Drug resistance  Human cancers  KRASG12Cmutation   Selective Covalent Targeting of Pyruvate Kinase M2 Using Arsenous Warheads 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 4, 页码: 2608-2621 作者:  Wang, Jingyao;  Zhou, Shaoqing;  Cheng, Yan;  Cheng, Lin;  Qin, Ying   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/03/27 Design, synthesis and biological evaluation of KRASG12C-PROTACs 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 78, 页码: 14 作者:  Zhang, Xiaoyi;  Zhao, Tong;  Sun, Minghao;  Li, Pei;  Lai, Mengzhen   |  收藏  |  浏览/下载：13/0  |  提交时间：2023/04/10 KRASG12C  PROTAC  Covalent inhibitors  Structure-activity relationships (SARs)  Anticancer