中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [97]
采集方式
OAI收割 [97]
内容类型
期刊论文 [97]
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2024 [2]
2023 [7]
2022 [5]
2021 [4]
2020 [5]
2019 [5]
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Chemistry [19]
Pharmacol... [14]
Biochemist... [8]
Spectrosco... [3]
Biophysics [2]
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浏览/检索结果:
共97条,第1-10条
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专题:上海药物研究所
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MATLAB language assisted data acquisition and processing in liquid chromatography Orbitrap mass spectrometry: Application to the identification and differentiation of Radix Bupleuri from its adulterants
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY A, 2024, 卷号: 1714, 页码: 10
作者:
Shen, Xuan-jing
;
Zhang, Jian-qing
;
An, Ya-ling
;
Yang, Lin
;
Li, Xiao-lan
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/02/27
Radix Bupleuri
Adulterants
MATLAB
precursor ion list (PIL)
identification
Metabolite characterisation of the peptide-drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS
期刊论文
OAI收割
XENOBIOTICA, 2024, 页码: 9
作者:
Yuan, Yali
;
Wang, Weiqiang
;
Luo, Jing
;
Tang, Chongzhuang
;
Zheng, Yuandong
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/02/19
peptide-drug conjugate
PDC
LN005
metabolite identification
liver S9s
Pharmacokinetic and metabolite profile of orally administered anemoside B4 in rats with an improved exposure in formulations of rectal suppository
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2023, 卷号: 315, 页码: 11
作者:
Ye, Yaqing
;
Xue, Mingzhen
;
Tian, Xiaoting
;
Gao, Hongwei
;
Hu, Pei
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/17
Anemoside B4
Pulsatilla chinensis
metabolite identification
Pharmacokinetics
Rectal suppository
A MS-feature-based medicinal plant database-driven strategy for ingredient identification of Chinese medicine prescriptions
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 卷号: 234, 页码: 10
作者:
Hou, Jianru
;
Yao, Changliang
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/10/17
Chinese medicine prescription
Ingredient identification
UPLC-Q
TOF
Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR & gamma; antagonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 15
作者:
Mei, Lianghe
;
Xu, Lansong
;
Wu, Sanan
;
Wang, Yafang
;
Xu, Chao
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2023/10/17
Betulinic acid
ROR & gamma
Target identification
Rationale structure optimization
Anti-tumor effects
antagonists
ETCM v2.0: An update with comprehensive resource and rich annotations for traditional Chinese medicine
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 6, 页码: 2559-2571
作者:
Zhang, Yanqiong
;
Li, Xin
;
Shi, Yulong
;
Chen, Tong
;
Xu, Zhijian
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
Traditional Chinese medicine
Database
Target identification
Network visualization
New drug research and development
Molecular mechanism
Quality marker
Drug repurposing
Privileged heterocycles for DNA-encoded library design and hit-to-lead optimization
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 248, 页码: 26
作者:
Wen, Xin
;
Wu, Xinyuan
;
Jin, Rui
;
Lu, Xiaojie
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/04/10
DNA Encoded library
Drug discovery
Heterocycles
Hit identification
Lead generation
Pseudotargeted Metabolomics Approach Enabling the Classification-Induced Ginsenoside Characterization and Differentiation of Ginseng and Its Compound Formulation Products
期刊论文
OAI收割
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2023, 页码: 13
作者:
Wang, Xiaoyan
;
Jiang, Meiting
;
Lou, Jia
;
Zou, Yadan
;
Liu, Meiyu
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2023/04/10
ginseng
ginsenoside
triple quadrupole-linear ion trap mass spectrometry
classified identification
pseudotargeted metabolomics
identification marker
Pharmacokinetics,mass balance,and metabolism of 14C TPN171,a novel PDE5 inhibitor,in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 1, 页码: 221
作者:
He Yifei
;
Liu Yin
;
Yu Jinghua
;
Cheng Huan
;
Odilov Abdullajon
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/05/22
TPN171
14CTPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance
Deep chemical identification of phytoecdysteroids in Achyranthes bidentata Blume by UHPLC coupled with linear ion trap-Orbitrap mass spectrometry and targeted isolation
期刊论文
OAI收割
CHINESE JOURNAL OF NATURAL MEDICINES, 2022, 卷号: 20, 期号: 7, 页码: 551-560
作者:
Wang Ying-Ying
;
Li Jia-Yuan
;
Yao Chang-Liang
;
Zhang Jian-Qing
;
Yu Yang
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/09/30
Achyranthes bidentata Blume
Chemical identification
Fragmentation behaviors
Phytoecdysteroids
Targeted isolation