中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [19]
合肥物质科学研究院 [9]
地理科学与资源研究所 [2]
过程工程研究所 [2]
上海有机化学研究所 [2]
生态环境研究中心 [2]
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采集方式
OAI收割 [39]
内容类型
期刊论文 [39]
发表日期
2025 [1]
2024 [2]
2023 [7]
2022 [6]
2021 [2]
2020 [4]
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学科主题
Environmen... [1]
有机化学 [1]
氟化学 [1]
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浏览/检索结果:
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Dynamic Cap-Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease
期刊论文
OAI收割
ADVANCED SCIENCE, 2025, 页码: 13
作者:
Su, Haixia
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/05/27
covalent inhibitors
I7L protease
monkeypox virus
protein structures
substrate proteolysis
The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring
期刊论文
OAI收割
CELL REPORTS, 2024, 卷号: 43, 期号: 10, 页码: 23
作者:
Shen, Chunxiang
;
Zhu, Xinyi
;
Chang, Hao
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/11/05
Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 10
作者:
Chen, Guofeng
;
Xie, Hang
;
Liu, Jiayuan
;
Shao, Qiang
;
Li, Minjun
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/01/26
Methyl substitution
Selectivity
FABP4 inhibitor
Anti-inflammation
Metabolic stability
Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14
作者:
Liu, Jiayuan
;
Zhang, Xianglei
;
Chen, Guofeng
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2024/01/16
Phosphodiesterase-4 (PDE4)
PDE5
Inhibitor
Drug repurposing
Crystal structure
Structure -guided optimization
Discovery of novel cGAS inhibitors based on natural flavonoids
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 14
作者:
Li, Jiameng
;
Xiong, Muya
;
Liu, Jiayuan
;
Zhang, Fengping
;
Li, Minjun
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2023/12/08
Cyclic GMP-AMP synthase
Inhibitor
Flavonoids
Crystal structure
Virtual screening
Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 15
作者:
Jiang, Xiangrui
;
Su, Haixia
;
Shang, Weijuan
;
Zhou, Feng
;
Zhang, Yan
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2024/03/25
Ootheca mantidis mitigates renal fibrosis in mice by the suppression of apoptosis via increasing the gut microbe
Akkermansia
muciniphila
and modulating glutamine metabolism
期刊论文
OAI收割
BIOMEDICINE & PHARMACOTHERAPY, 2023, 卷号: 166, 页码: 15
作者:
Wang, Jue
;
Guo, Xiaozhen
;
Zou, Ziyuan
;
Yu, Minjun
;
Li, Xueling
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2023/12/08
Ootheca mantidis
Unilateral ureteral obstruction
Renal interstitial fibrosis
Apoptosis
Akkermansia muciniphila
Glutamine
Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 10, 页码: 15
作者:
Wang, Qian
;
Chen, Guofeng
;
He, Jian
;
Li, Jiameng
;
Xiong, Muya
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2023/10/17
SARS-CoV-2
papain-like protease
covalent inhibitor
co-crystal structure
in vitro assay
High-precision early warning system for rice cadmium accumulation risk assessment
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 卷号: 859
作者:
Yan, Huili
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/03/07
Genotype-to-phenotype prediction
Rice
Cd risk early warning
Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines
期刊论文
OAI收割
BIOCHEMICAL PHARMACOLOGY, 2023, 卷号: 207, 页码: 16
作者:
Gao, Jing
;
Zhou, Chen
;
Zhong, Yan
;
Shi, Li
;
Luo, Xuanyang
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2023/04/10
HSP90
ATP competitive inhibitors
Tip-based affinity selection-mass spectrometry
Dipyridamole
Cell cycle regulators