机构

• 上海药物研究所 [14]
• 昆明植物研究所 [5]
• 烟台海岸带研究所 [3]
• 上海生物化学与细胞生... [2]
• 生物物理研究所 [1]
• 南海海洋研究所 [1]
• 更多

采集方式

• OAI收割 [33]

内容类型

• 期刊论文 [33]

发表日期

• 2025 [2]
• 2024 [1]
• 2023 [4]
• 2021 [2]
• 2020 [2]
• 2018 [3]
• 更多

学科主题

• Chemistry [3]
• Pharmacolo... [3]
• Hematology... [2]
• Plant Scie... [2]
• Behavioral... [1]
• Biochemist... [1]
• 更多

筛选

浏览/检索结果: 共33条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Patients With Mild or Moderate Hepatic Impairment Versus Participants With Normal Hepatic Function: A Phase I Study 期刊论文  OAI收割 CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 7 作者:  Zhou, Jing;  Zhang, Hong;  Ding, Yanhua;  Wang, Zhen;  Wang, Yu   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/06/23 hepatic impairment  pharmacokinetics  phosphodiesterase-5 inhibitor  TPN171   A Phase I Study to Evaluate the Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Adults with Renal Impairment 期刊论文  OAI收割 CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 8 作者:  Fu, Ping;  Song, Yi;  Hu, Chao;  Yong, Xiaolan;  Yu, Yang   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/06/23 pharmacokinetics  phosphodiesterase 5 inhibitor  renal impairment  safety  TPN171   Phylogenetic distribution and characterization of conserved C-di-GMP metabolizing proteins in filamentous cyanobacterium Arthrospira 期刊论文  OAI收割 GENE, 2024, 卷号: 927, 页码: 11 作者:  Wang, Kang;  Li, Wenjun;  Cui, Hongli;  Qin, Song   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/12/06 Arthrospira  c-di-GMP  Diguanylate cyclase  Phosphodiesterase  Extracellular polymeric substances   Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei;  Chen, Guofeng;  Shao, Qiang;  Zou, Yi   |  收藏  |  浏览/下载：38/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   Phylogenetic Analysis and Characterization of Diguanylate Cyclase and Phosphodiesterase in Planktonic Filamentous Cyanobacterium Arthrospira sp. 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 20, 页码: 11 作者:  Wang, Kang;  Li, Wenjun;  Cui, Hongli;  Qin, Song   |  收藏  |  浏览/下载：44/0  |  提交时间：2024/01/26 c-di-GMP  Arthrospira  diguanylate cyclase  phosphodiesterase  riboswitch   Phylogenetic Analysis and Characterization of Diguanylate Cyclase and Phosphodiesterase in Planktonic Filamentous Cyanobacterium Arthrospira sp. 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 20, 页码: 11 作者:  Wang, Kang;  Li, Wenjun;  Cui, Hongli;  Qin, Song   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/11/02 c-di-GMP  Arthrospira  diguanylate cyclase  phosphodiesterase  riboswitch   Discovery of 2-(Methylcarbonylamino) thiazole as PDE4 inhibitors via virtual screening and biological evaluation 期刊论文  OAI收割 JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 124, 页码: 108567 作者:  Ma,Rui;  Song,Na;  Wang,Lveli;  Gu,Xi;  Xiong,Feng   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/07/22 PHOSPHODIESTERASE-4 INHIBITOR  ACCURATE DOCKING  APREMILAST  EFFICACY  INSIGHTS  DISEASE  ASTHMA  POTENT  GLIDE   PDE4B Induces Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Is Transcriptionally Suppressed by CBX7 期刊论文  OAI收割 FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 卷号: 9, 页码: 12 作者:  Huang, Zhengnan;  Liu, Jiakuan;  Yang, Jiale;  Yan, Yilin;  Yang, Chenkai   |  收藏  |  浏览/下载：44/0  |  提交时间：2022/06/15 phosphodiesterase 4B  urinary bladder cancer  chromobox protein homolog 7  epithelial-to-mesenchymal transition  beta-catenin   Robustadial A and B from Eucalyptus globulus Labill. and their anticancer activity as selective tyrosyl-DNA phosphodiesterase 2 inhibitors 期刊论文  OAI收割 PHYTOTHERAPY RESEARCH, 2021, 卷号: 35, 期号: 9, 页码: 5282-5289 作者:  Zhang,Yu;  He,Xiao-Zhi;  Yang,Hao;  Liu,Hai-Yang;  An,Lin-Kun   |  收藏  |  浏览/下载：25/0  |  提交时间：2022/04/02 anticancer  Eucalyptus globulus Labill  inhibitors  synergistic effect  tyrosyl-DNA phosphodiesterase  SMALL-MOLECULE INHIBITORS  1 TDP1   Therapy for Apnoea of Prematurity: A Retrospective Study on Effects of Standard Dose and Genetic Variability on Clinical Response to Caffeine Citrate in Chinese Preterm Infants 期刊论文  OAI收割 ADVANCES IN THERAPY, 2020, 页码: 20 作者:  He, Xin;  Qiu, Jin-Chun;  Lu, Ke-Yu;  Guo, Hong-Li;  Li, Ling   |  收藏  |  浏览/下载：40/0  |  提交时间：2020/12/24 Adenosine receptors  AHR  AOP  Caffeine  Phosphodiesterase  Polymorphism  Therapeutic drug monitoring