机构

• 上海药物研究所 [13]
• 上海应用物理研究所 [1]

采集方式

• OAI收割 [14]

内容类型

• 期刊论文 [14]

发表日期

• 2024 [2]
• 2023 [1]
• 2022 [1]
• 2020 [2]
• 2019 [1]
• 2016 [2]
• 更多

学科主题

筛选

浏览/检索结果: 共14条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Update on the development of TGR5 agonists for human diseases 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 271, 页码: 20 作者:  Jin, Wangrui;  Zheng, Mingyue;  Chen, Yihua;  Xiong, Hai   |  收藏  |  浏览/下载：14/0  |  提交时间：2024/07/12 Bile acids  TGR5  T2DM  Gut-targeted TGR5 agonists   Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 144, 页码: 18 作者:  Zhuo, Ning;  Yun, Ying;  Zhang, Chenlu;  Guo, Shimeng;  Yin, Jianpeng   |  收藏  |  浏览/下载：33/0  |  提交时间：2024/03/25 Type 2 Diabetes  TGR5 agonist  Betulinic acid  Gut-restricted  Gallbladder-filling effects  Kinetophores   TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 8, 页码: 1649-1664 作者:  Yang, Wen-ji;  Han, Fang-hui;  Gu, Yi-pei;  Qu, Hui;  Liu, Jia   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/03/27 TGR5 agonist  ulcerative colitis  intestinal epithelial cell  apoptosis  cAMP  PKA signaling pathway  c-FLIP   Design and exploration of gut-restricted bifunctional molecule with TGR5 agonistic and DPP4 inhibitory effects for treating ulcerative colitis 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 242, 页码: 114697 作者:  Han, Fanghui;  Ning, Mengmeng;  Wang, Kai;  Gu, Yipei;  Qu, Hui   |  收藏  |  浏览/下载：26/0  |  提交时间：2024/03/21 Bifunctional molecule  Gut-restricted  Ulcerative colitis  TGR5  DPP4   A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters 期刊论文  OAI收割 TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 卷号: 404, 页码: 14 作者:  Wang, Ying;  Zhu, Yao;  Niu, Junxing;  Deng, Qiangqiang;  Guo, Shimeng   |  收藏  |  浏览/下载：60/0  |  提交时间：2020/12/21 Bile acid analog  NASH  TGR5  Cd36  AMPK alpha   Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 12 作者:  Han, Fanghui;  Ning, Mengmeng;  Cao, Hua;  Ye, Yangliang;  Feng, Ying   |  收藏  |  浏览/下载：28/0  |  提交时间：2020/12/21 Soft drug  TGR5  GLP-1  Gallbladder-filling effects  Rapid metabolism  Carboxylic ester   TGR5 agonist ameliorates insulin resistance in skeletal muscles and improves glucose homeostasis in diabetic mice 期刊论文  OAI收割 METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 卷号: 99, 页码: 45-56 作者:  Huang, Suling;  Ma, Shanyao;  Ning, Mengmeng;  Yang, Wenji;  Ye, Yangliang   |  收藏  |  浏览/下载：39/0  |  提交时间：2020/07/01 TGR5  Glucose homeostasis  Insulin resistance  Skeletal muscle  Type 2 diabetes   OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 10, 页码: 1359-1369 作者:  Ma, Shan-yao;  Ning, Meng-meng;  Zou, Qing-an;  Feng, Ying;  Ye, Yang-liang   |  收藏  |  浏览/下载：40/0  |  提交时间：2019/01/08 OL3  MN6  linagliptin  TGR5 agonist  DPP4 inhibitor  GLP-1  low-absorbed  gallbladder filling  type 2 diabetes mellitus   ol3anovellowabsorbedtgr5agonistwithreducedsideeffectsloweredbloodglucoseviadualactionsontgr5activationanddpp4inhibition 期刊论文  OAI收割 actapharmacologicasinica, 2016, 卷号: 000, 期号: 010, 页码: 1359 作者:  Ma Shanyao;  Ning Mengmeng;  Zou Qingan;  Feng Ying;  Ye Yangliang   |  收藏  |  浏览/下载：17/0  |  提交时间：2020/07/01 OL3  MN6  linagliptin  TGR5 agonist  DPP4 inhibitor  GLP-1  low-absorbed  gallbladder filling  type 2 diabetes mellitus   Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 11, 页码: 1463-1472 作者:  Wang, Xiao-yin;  Zhang, Shu-yong;  Li, Jing;  Liu, Hua-nan;  Xie, Xin   |  收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08 TGR5  activator  betulinic acid derivatives  GLP-1  lipophilic  structure modifications