机构

• 上海药物研究所 [385]
• 大连化学物理研究所 [35]
• 生态环境研究中心 [32]
• 昆明植物研究所 [28]
• 西北高原生物研究所 [25]
• 上海生物化学与细胞... [18]
• 更多

采集方式

• OAI收割 [639]
• iSwitch采集 [22]

内容类型

• 期刊论文 [634]
• 学位论文 [22]
• 会议论文 [4]
• 其他 [1]

发表日期

• 2023 [31]
• 2022 [31]
• 2021 [42]
• 2020 [28]
• 2019 [25]
• 2018 [40]
• 更多

学科主题

• Pharmacol... [19]
• Biochemis... [12]
• Neuroscie... [12]
• Chemistry [10]
• 物理化学 [7]
• Biophysics [4]
• 更多

筛选

浏览/检索结果: 共661条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 144, 页码: 18 作者:  Zhuo, Ning;  Yun, Ying;  Zhang, Chenlu;  Guo, Shimeng;  Yin, Jianpeng   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/25 Type 2 Diabetes  TGR5 agonist  Betulinic acid  Gut-restricted  Gallbladder-filling effects  Kinetophores   Exploration of the potential association between GLP-1 receptor agonists and suicidal or self-injurious behaviors: a pharmacovigilance study based on the FDA Adverse Event Reporting System database 期刊论文  OAI收割 BMC MEDICINE, 2024, 卷号: 22, 期号: 1, 页码: 13 作者:  Zhou, Jianxing;  Zheng, You;  Xu, Baohua;  Long, Songjun;  Zhu, Li-e   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/03/25 GLP-1RAs  Suicidal or self-injurious behaviors  Pharmacovigilance  FAERS database  Type 2 diabetes  Obesity   Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 20 作者:  Yang, Wenjiao;  Gong, Xudong;  Sun, Haiguo;  Wu, Chunhui;  Suo, Jin   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/03/06 CB2R agonist  5-HT1AR agonist  CB1R antagonist  Antidepressant  Anxiolytic   Application of ensemble learning for predicting GABAA receptor agonists 期刊论文  OAI收割 COMPUTERS IN BIOLOGY AND MEDICINE, 2024, 卷号: 169, 页码: 13 作者:  Xiao, Fu;  Ding, Xiaoyu   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/03/25 GABA(A )receptor  Benzodiazepine  Agonist  Machine learning  Classification   Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 96, 页码: 12 作者:  Song, Zhaoxiang;  Lu, Dan;  Sun, Jun;  Ye, Yangliang;  Fang, Jiahui   |  收藏  |  浏览/下载：26/0  |  提交时间：2024/01/16 GPR35  IBD  Lodoxamide   Synthesis, evaluation and molecular dynamics study of human toll-like receptor 2/6 specific monoacyl lipopeptides as candidate immunostimulants 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 141, 页码: 17 作者:  Zhu, Yueyue;  Liu, Bo;  Chen, Zonglong;  Wang, Xianyang;  Wang, Yujie   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Toll -like receptor 2/6 agonists  PamCS  Structure-activity relationship  Lipopeptide  Immunostimulants   Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2 期刊论文  OAI收割 CELL REPORTS, 2023, 卷号: 42, 期号: 11, 页码: 19 作者:  Zhu, Shengnan;  Yuan, Qingning;  Li, Xinzhu;  He, Xinheng;  Shen, Shiyi   |  收藏  |  浏览/下载：99/0  |  提交时间：2024/01/16 different ligands  recognition  ligand selectivity  receptor   Circuit-specific gene therapy reverses core symptoms in a primate Parkinson's disease model 期刊论文  OAI收割 CELL, 2023, 卷号: 186, 期号: 24, 页码: 5394-+ 作者:     |  收藏  |  浏览/下载：6/0  |  提交时间：2024/01/26 The new direction of drug development: Degradation of undruggable targets through targeting chimera technology 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2023, 页码: 54 作者:  Liang, Xuewu;  Ren, Hairu;  Han, Fengyang;  Liang, Renwen;  Zhao, Jiayan   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/01/16 chimeric design  degradation System  PROTAC  targeted degradation technology  undruggable targets   Identification of a carbohydrate recognition motif of purinergic receptors 期刊论文  OAI收割 ELIFE, 2023, 卷号: 12, 页码: 17 作者:  Zhao, Lifen;  Wei, Fangyu;  He, Xinheng;  Dai, Antao;  Yang, Dehua   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/02/19 G-protein coupled receptor  sugar nucleotide  recogonition mechanism  functional motif  Human