中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Development of Potent MALT1 Inhibitors Featuring a Novel "2-Thioxo-2,3-dihydrothiazolo[4,5-
d
]pyrimidin-7(6
H
)-one" Scaffold for the Treatment of B Cell Lymphoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 4, 页码: 2884-2906
作者:
Liang, Xuewu
;
Yu, Haolan
;
Liang, Renwen
;
Feng, Zhuanghui
;
Saidahmatov, Abdusaid
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/04/09
Design, synthesis and biological evaluation of betulinic acid derivatives as potential inhibitors of 3CL-protease of SARS-CoV-2
期刊论文
OAI收割
STEROIDS, 2024, 卷号: 202, 页码: 8
作者:
Liu, Yaowen
;
Nie, Tianqing
;
Hou, Jinjun
;
Long, Huali
;
Zhang, Zijia
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/03/13
3CLpro
SARS-CoV-2
Betulinic acid
Natural product
Inhibitory activity
Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 17
作者:
Zhang, Ranran
;
Wang, Pengyu
;
Wei, Bingyan
;
Chen, Liang
;
Song, Xiaomin
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/10/17
ClpP agonists
Structure-activity relationship
Mitochondrial respiratory chain
Antileukemic therapy
Therapeutic potential of enzymatically extracted eumelanin from squid ink in type 2 diabetes mellitus ICR mice: Multifaceted intervention against hyperglycemia, oxidative stress and depression
期刊论文
OAI收割
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2023, 页码: 15
作者:
Song, Wen
;
Xing, Ronge
;
Yang, Haoyue
;
Liu, Song
;
Yu, Huahua
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/11/30
type 2 diabetes mellitus (T2DM)
eumelanin
hypoglycemic activity
antioxidant activity
antidepressant activity
Expression patterns and antifungal function study of KaSPI in
Mythimna separata
期刊论文
OAI收割
BULLETIN OF ENTOMOLOGICAL RESEARCH, 2023, 页码: 11
作者:
Chen, Ya-Ru
;
Yang, Hong-Jia
;
Cha, Jin-Myong
;
Zhang, Xin-Xin
;
Fan, Dong
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/07
Beauveria bassiana
enzyme activity
Mythimna separata
RNA interference
serine protease inhibitor
Efficacy and safety of SIM0417 (SSD8432) plus ritonavir for COVID-19 treatment: a randomised, double-blind, placebo- controlled, phase 1b trial
期刊论文
OAI收割
LANCET REGIONAL HEALTH-WESTERN PACIFIC, 2023, 卷号: 38, 页码: 13
作者:
Wang, Fuxiang
;
Xiao, Wen
;
Tang, Yimin
;
Cao, Mengli
;
Shu, Dan
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/10/17
Covid-19
3CL protease inhibitor
SARS-CoV-2 viral load
Alleviation of COVID-19 symptoms
Preparation and characterization of nanobodies targeting SARS-CoV-2 papain-like protease
期刊论文
OAI收割
PROTEIN EXPRESSION AND PURIFICATION, 2023, 卷号: 207, 页码: 106267
作者:
Qiao, Huarui
;
Li, Lingyun
;
Wang, Lu
;
Yu, Haijun
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/03/27
SARS-CoV-2
Papain like protease (PLpro)
Nanobody
PLpro inhibitor
Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches
期刊论文
OAI收割
CHEMICAL SCIENCE, 2023, 卷号: 14, 期号: 18, 页码: 4681-4696
作者:
Shao, Qiang
;
Xiong, Muya
;
Li, Jiameng
;
Hu, Hangchen
;
Su, Haixia
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/03/27
Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2
期刊论文
OAI收割
European journal of medicinal chemistry, 2023, 卷号: 249, 页码: 115129
作者:
Ren, Pengxuan
;
Yu, Changyue
;
Zhang, Ruxue
;
Nie, Tianqing
;
Hu, Qiaoyu
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/03/26
Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2
期刊论文
OAI收割
Signal Transduction and Targeted Therapy, 2023, 卷号: 8, 期号: 5, 页码: 2384-2391
作者:
Xu, Zhijian
;
Shi, Danrong
;
Han, Jianbao
;
Ling, Yun
;
Jiang, Xiangrui
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/03/27