中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [163]
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PRMT1 Inhibition Activates the Interferon Pathway to Potentiate Antitumor Immunity and Enhance Checkpoint Blockade Efficacy in Melanoma
期刊论文
OAI收割
CANCER RESEARCH, 2024, 卷号: 84, 期号: 3, 页码: 419-433
作者:
Tao, Hongru
;
Jin, Chen
;
Zhou, Liyuan
;
Deng, Zhenzhong
;
Li, Xiao
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/04/09
Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14
作者:
Liu, Jiayuan
;
Zhang, Xianglei
;
Chen, Guofeng
;
Shao, Qiang
;
Zou, Yi
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/01/16
Phosphodiesterase-4 (PDE4)
PDE5
Inhibitor
Drug repurposing
Crystal structure
Structure -guided optimization
Rational design of oral delivery nanosystems for hypoglycemic peptides
期刊论文
OAI收割
NANO TODAY, 2023, 卷号: 53, 页码: 19
作者:
Peng, Taoxing
;
Shao, Xinyue
;
Long, Li
;
Liu, Han
;
Song, Wenqin
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/01/16
Hypoglycemic peptides
Oral delivery
Mucus penetration
Endocytosis
Intracellular trafficking
Exocytosis
Autophagy contributes to increase the content of intracellular free amino acids in hard clam
(Mercenaria
mercenaria)
during prolonged exposure to hypersaline environments
期刊论文
OAI收割
MARINE ENVIRONMENTAL RESEARCH, 2023, 卷号: 192, 页码: 11
作者:
Zhou, Cong
;
Yang, Mei-jie
;
Hu, Zhi
;
Zou, Yan
;
Shi, Pu
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/11/30
Hyposalinity
Hypersalinity
Transcriptome
Autophagy
Free amino acids
PRDX1 Cys52Ser variant alleviates nonalcoholic steatohepatitis by reducing inflammation in mice
期刊论文
OAI收割
MOLECULAR METABOLISM, 2023, 卷号: 76, 页码: 9
作者:
Bai, Zhonghao
;
Yin, Wen
;
Liu, Rui
;
Tang, Minglei
;
Shi, Xiaokeng
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/08
PRDX1
NASH
Inflammation
Cys52
NF-KB
STAT1
Phylogenetic Analysis and Characterization of Diguanylate Cyclase and Phosphodiesterase in Planktonic Filamentous Cyanobacterium
Arthrospira
sp.
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 20, 页码: 11
作者:
Wang, Kang
;
Li, Wenjun
;
Cui, Hongli
;
Qin, Song
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/01/26
c-di-GMP
Arthrospira
diguanylate cyclase
phosphodiesterase
riboswitch
A zinc-modified
Anemarrhena asphodeloides
polysaccharide complex enhances immune activity
via
the NF-?B and MAPK signaling pathways
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 卷号: 249, 页码: 12
作者:
Zhang, Shaojie
;
Zhang, Qian
;
Li, Chong
;
Xing, Na
;
Zhou, Pengfei
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/08
Anemarrhena asphodeloides Bunge
Zinc modification
Immunoregulatory activity
Zebrafish
NF-kappa B signaling pathway
MAPKs signaling pathway
The ancient CgPEPCK-1, not CgPECK-2, evolved into a multifunctional molecule as an intracellular enzyme and extracellular PRR
期刊论文
OAI收割
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2023, 卷号: 145, 页码: 13
作者:
Yin, Xiaoting
;
Qiu, Limei
;
Long, Dandan
;
Lv, Zhao
;
Liu, Qing
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/13
PEPCK
Gene evolution and differentiation
PRR
Catalyzing enzyme
Biological Function of Pin1 in Vivo and Its Inhibitors for Preclinical Study: Early Development, Current Strategies, and Future Directions
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 14, 页码: 9251-9277
作者:
He, Siyu
;
Li, Linjie
;
Jin, Rui
;
Lu, Xiaojie
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/10/17
CD71-mediated liposomal arsenic-nickel complex combined with all-trans retinoic acid for the efficacy of acute promyelocytic leukemia
期刊论文
OAI收割
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 18, 期号: 4, 页码: 16
作者:
Liu, Xiao
;
Zhang, Lili
;
Yang, Yueying
;
Yin, Weiwei
;
Liu, Yunhu
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/10/17
Transferrin
Arsenic trioxide
Acute promyelocytic leukemia
Liposome
All-trans retinoic acid