机构

• 上海药物研究所 [25]
• 合肥物质科学研究院 [11]
• 西北高原生物研究所 [10]
• 广州生物医药与健康研... [5]
• 化学研究所 [4]
• 大连化学物理研究所 [3]
• 更多

采集方式

• OAI收割 [64]
• iSwitch采集 [1]

内容类型

• 期刊论文 [64]
• 学位论文 [1]

发表日期

• 2023 [4]
• 2022 [3]
• 2021 [5]
• 2019 [3]
• 2018 [3]
• 2017 [10]
• 更多

学科主题

• Pharmacolo... [5]
• Chemistry [2]
• 氟化学 [2]
• 物理化学 [2]
• Oncology [1]
• Research &... [1]
• 更多

筛选

浏览/检索结果: 共65条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Design and synthesis of 1H-pyrazolo[3,4-d]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 18 作者:  Zhang, Junjie;  Li, Yan;  Tang, Haotian;  Zhou, Qianqian;  Tong, Linjiang   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Cancer immunotherapy  HPK1  Structure -based design  HPK1 inhibitor   Discovery of 4-oxo-4,5-dihydropyrazolo[1,5-a]quinoxaline-7-carboxamide derivatives as PI3K alpha inhibitors via virtual screening and docking-based structure optimization 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 86, 页码: 15 作者:  Gu, Dongyan;  Zhang, Mengmeng;  Cai, Lvtao;  Wang, Chang;  Zhou, Yu -Bo   |  收藏  |  浏览/下载：7/0  |  提交时间：2023/10/17 PI3K alpha inhibitors  Virtual screening  Structure optimization   Synthesis and Biological Evaluation of Sclareolide-Indole Conjugates and Their Derivatives 期刊论文  OAI收割 MOLECULES, 2023, 卷号: 28, 期号: 4, 页码: 1737 作者:  Cheng, Ying;  Lyu, Xilin;  Liu, Chen;  Wang, Xiancheng;  Cheng, Jing   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/03/27 sclareolide  indole  polyphenol  acetal  antitumor activity   Construction of Vinyl-Substituted N-Heterocycles via Rh(III)- Catalyzed C-H Functionalization/Annulation of Pyrazolidinones 期刊论文  OAI收割 ADVANCED SYNTHESIS & CATALYSIS, 2023, 页码: 7 作者:  Zhang, Shurui;  Hu, Shulei;  Wang, Kean;  Yang, Zhao;  Liu, Hong   |  收藏  |  浏览/下载：12/0  |  提交时间：2023/04/10 annulation reactions  C-H activation  pyrazolidinone  Rh(III)-catalyzed   Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study 期刊论文  OAI收割 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1411-1425 作者:  Sun, Yin;  Tang, Haotian;  Wang, Xiaoyan;  Feng, Fang;  Fan, Tiantian   |  收藏  |  浏览/下载：36/0  |  提交时间：2022/08/16 TBK1 inhibitors  1H-pyrazolo[3  4-b]pyridine  structure-activity relationships (SARs)  immune response  cancer therapy   Dual-acting antitumor agents targeting the A2A adenosine receptor and histone deacetylases: Design and synthesis of 4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine derivatives 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 236, 页码: 114326 作者:  Zhang, Jinfeng;  Luo, Ziwei;  Duan, Wenwen;  Yang, Kexin;  Ling, Lijun   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/03/21 Bifunctional  Structure-based  Cancer  Immunotherapy   Discovery of Pyrazolo[3,4-d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 1, 页码: 103-119 作者:  Tan, Xiaoqin;  Li, Chunpu;  Yang, Ruirui;  Zhao, Sen;  Li, Fei   |  收藏  |  浏览/下载：33/0  |  提交时间：2022/06/15 Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13 作者:  Chen, Yun;  Bai, Gang;  Li, Yan;  Ning, Yi;  Cao, Sufen   |  收藏  |  浏览/下载：58/0  |  提交时间：2021/12/01 FLT3  FLT3-ITD  Acute myeloid leukemia  Structure-activity relationships  Pyrazolo[1, 5-a]pyrimidine   Synthesis and Evaluation of 3-(Indol-3-yl)-4-(Pyrazolo[3,4-c]Pyridazin-3-yl)-Maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors 期刊论文  OAI收割 PHARMACEUTICAL CHEMISTRY JOURNAL, 2021, 卷号: 55, 期号: 7, 页码: 655-664 作者:  Xu, Jianghong;  Hu, Yuanyuan;  Liu, Xiaoqi;  Gao, Anhui   |  收藏  |  浏览/下载：47/0  |  提交时间：2021/12/01 IDH1-R132H inhibitors  synthesis  biological activity  docking  3-(indol-3-yl)-4-(pyrazolo-[3  4-c]pyridazin-3-yl)-maleimides   Synthesis of Pyrazolo[1,2-a]cinnolines via Rhodium(III)-Catalyzed [4+2] Annulation Reactions of Pyrazolidinones with Sulfoxonium Ylides 期刊论文  OAI收割 ADVANCED SYNTHESIS & CATALYSIS, 2021, 页码: 8 作者:  Hu, Shulei;  Han, Xu   |  收藏  |  浏览/下载：13/0  |  提交时间：2021/08/17 annulation reactions  C-H activation  pyrazolidinone  Rhodium (III)-catalyzed  sulfoxonium ylide