中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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水生生物研究所 [17]
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上海生物化学与细胞生... [7]
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期刊论文 [60]
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内容类型:期刊论文
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Loops Mediate Agonist-Induced Activation of the Stimulator of Interferon Genes Protein
期刊论文
OAI收割
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2023, 页码: 9
作者:
Li, Rui
;
Chen, Lin
;
He, Xinheng
;
Cao, Duanhua
;
Zhang, Zehong
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/11
Design, synthesis, and STING-agonistic activity of benzo[
b
]thiophene-2-carboxamide derivatives
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2023, 页码: 10
作者:
Zhou, Rongyao
;
Wang, Xiyuan
;
Zhang, Deqiang
;
Zhan, Zhengsheng
;
Duan, Wenhu
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/08
STING
CDN
Benzo[b]thiophene-2-carboxamide
Cellular activity
Structure-Activity Relationship Study of 1H-Pyrrole-3-carbonitrile Derivatives as STING Receptor Agonists
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2023, 页码: 9
作者:
Shen, Chang
;
Xu, Peijia
;
Zhang, Changfa
;
Su, Zhaoming
;
Shan, Bin
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/10/17
cGAS-STING signaling pathway
STING agonists
antitumor immunity
anti-infection immunity
Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 247, 页码: 115034
作者:
Song, Shukai
;
Tang, Haotian
;
Ran, Ting
;
Fang, Feng
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/03/27
SyntaLinker
Generative modelling
TBK1 inhibitor
pyrrolo[2
3-d]pyrimidine
Structure-activity relationship
Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1411-1425
作者:
Sun, Yin
;
Tang, Haotian
;
Wang, Xiaoyan
;
Feng, Fang
;
Fan, Tiantian
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/08/16
TBK1 inhibitors
1H-pyrazolo[3
4-b]pyridine
structure-activity relationships (SARs)
immune response
cancer therapy
Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 238, 页码: 16
作者:
Niu, Jing
;
Bai, Hudagula
;
Li, Zizhou
;
Gao, Yuzhe
;
Zhang, Yan
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/08/16
STING
cGAS
Non-cyclic dinucleotides (non-CDNs)
Systemic administration
Antitumor immunotherapy
TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery
期刊论文
OAI收割
DRUG DISCOVERY TODAY, 2021, 卷号: 26, 期号: 10, 页码: 2445-2455
作者:
Xiang, Shuang
;
Song, Shukai
;
Tang, Haotian
;
Smaill, Jeff B.
;
Wang, Aiqun
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/12/01
Antibiotic resistance
Computational biology
Databases
In silico tools
Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation
期刊论文
OAI收割
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 169, 页码: 11
作者:
Bao, Weilian
;
Liu, Xiaohong
;
You, Yan
;
Hou, Hui
;
Wang, Xu
  |  
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2021/11/24
SNX10
IBD
Macrophage
PIKfyve
TBK1
PPI inhibitor
Molecular characterization of a cyprinid fish (Ancherythroculter nigrocauda) TBK1 and its kinase activity in IFN regulation
期刊论文
OAI收割
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021, 卷号: 114, 页码: 10
作者:
Chen, Jian
;
Zhou, Xiao-Yu
;
Li, Pei
;
Li, Zhuo-Cong
;
Zhang, Can
  |  
收藏
  |  
浏览/下载:133/0
  |  
提交时间:2020/12/31
TBK1
IFN
Antiviral
Ancherythroculter nigrocauda
Promoter activity
Caragana rosea Turcz Methanol Extract Inhibits Lipopolysaccharide-Induced Inflammatory Responses by Suppressing the TLR4/NF-kappa B/IRF3 Signaling Pathways
期刊论文
OAI收割
MOLECULES, 2021, 卷号: 26, 期号: 21
作者:
Mitra, Ankita
;
Ahuja, Akash
;
Rahmawati, Laily
;
Kim, Han Gyung
;
Woo, Byoung Young
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/02/24
Caragana rosea Turcz (Cr-ME)
anti-inflammatory activity
NF-kappa B and IRF3 signaling pathways