中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [360]
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OAI收割 [360]
内容类型
期刊论文 [357]
会议论文 [3]
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2024 [8]
2023 [26]
2022 [26]
2021 [25]
2020 [32]
2019 [14]
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专题:上海药物研究所
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Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 144, 页码: 18
作者:
Zhuo, Ning
;
Yun, Ying
;
Zhang, Chenlu
;
Guo, Shimeng
;
Yin, Jianpeng
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/25
Type 2 Diabetes
TGR5 agonist
Betulinic acid
Gut-restricted
Gallbladder-filling effects
Kinetophores
Ent-labdane-type diterpene glycosides obtained from
Rubus
chingii
Hu and their inhibitory effects on PDE5A activity
期刊论文
OAI收割
FITOTERAPIA, 2024, 卷号: 173, 页码: 14
作者:
Yu, Jun-dong
;
Wang, Jing-Yi
;
Liu, Jia-yuan
;
Xu, Ye-chun
;
Zhang, Xue
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/02/27
diterpene glycosides
Rubus Chingii Hu
PDE5A inhibitory activity
ent-labdane
Eleven highly oxygenated and anti-inflammatory guaian-8,12-olides from Hedyosmum orientale
期刊论文
OAI收割
TETRAHEDRON, 2024, 卷号: 152, 页码: 8
作者:
Fan, Yao-Yue
;
Zhang, Xin-Ru
;
Zheng, Cheng-Yu
;
Li, Ying
;
Yue, Jian-Min
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/25
Hedyosmum orientale
Natural products
Guaian-8,12-olide
Structure elucidation
Anti-inflammatory activity
Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1, 页码: 20
作者:
Miao, Yunqiu
;
Li, Lijun
;
Wang, Ying
;
Wang, Jiangyue
;
Zhou, Yihan
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/13
Discovery and exploration of novel somatostatin receptor subtype 5 (SSTR5) antagonists for the treatment of cholesterol gallstones
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 16
作者:
Han, Fanghui
;
Zhao, Tingting
;
Zhang, Yanglong
;
Yun, Ying
;
Xu, Yuanyuan
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/02/19
SSTR5 antagonist
Gallbladder emptying
Cholesterol gallstones
Discovery and optimization of thieno[3,2-d]pyrimidine derivatives as highly selective inhibitors of cyclin-dependent kinase 7
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 263, 页码: 21
作者:
Zhang, Hongjin
;
Lin, Guohao
;
Jia, Suyun
;
Zhang, Ying
;
Wu, Jianbo
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/01/26
Thieno[3
d ]pyrimidine derivative
Cyclin-dependent kinase 7
Small molecule inhibitor
Kinome selectivity
Triple negative breast cancer
The promise and challenges of combination therapies with antibody-drug conjugates in solid tumors
期刊论文
OAI收割
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2024, 卷号: 17, 期号: 1, 页码: 32
作者:
Wei, Qing
;
Li, Peijing
;
Yang, Teng
;
Zhu, Jiayu
;
Sun, Lu
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/02/27
Antibody-drug conjugate
Solid tumor
Combination therapy
Immunotherapy
Targeted therapy
Structure-based development of potent and selective type-II kinase inhibitors of RIPK1
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334
作者:
Qin, Ying
;
Li, Dekang
;
Qi, Chunting
;
Xiang, Huaijiang
;
Meng, Huyan
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/03/06
RIPK1
Necroptosis
Type-II kinase inhibitors
Rational design
Lead optimization
Structure-activity relationship
Anti-inflammation
Preclinical drug discovery
Ginsenoside Rg3 endows liposomes with prolonged blood circulation and reduced accelerated blood clearance
期刊论文
OAI收割
JOURNAL OF CONTROLLED RELEASE, 2023, 卷号: 364, 页码: 23-36
作者:
Xia, Jiaxuan
;
Chen, Chen
;
Dong, Meichen
;
Zhu, Ying
;
Wang, Anni
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/01/16
Ginsenoside Rg3
Liposomes
Polyethylene glycol
Long circulation
Accelerated blood clearance (ABC)
IgM antibody
Complement activation
Inhibiting Endothelial Cell-Mediated T Lymphocyte Apoptosis with Integrin-Targeting Peptide-Drug Conjugate Filaments for Chemoimmunotherapy of Triple-Negative Breast Cancer
期刊论文
OAI收割
ADVANCED MATERIALS, 2023, 页码: 12
作者:
Cai, Ying
;
Zhu, Binyu
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/01/16
Fas ligand
immunotherapy
peptide-drug conjugate
triple-negative breast cancer
tumor-associated endothelial cells