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浏览/检索结果: 共601条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses 期刊论文  OAI收割 NATURE CHEMICAL BIOLOGY, 2024, 页码: 29 作者:  Zhou, Xiaoyu;  Zhao, Cheng;  Xu, Haiyan;  Xu, Yixiang;  Zhan, Li   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/03/25 Discovery of GPX4 inhibitors through FP-based high-throughput screening 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 14 作者:  Cao, Yu;  Wu, Bin;  Xu, Ying;  Wang, Mingchen;  Wu, Xinyu   |  收藏  |  浏览/下载：26/0  |  提交时间：2024/02/27 GPX4 inhibitor  HTS assay  Ferroptosis  Fluorescence polarization   Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation 期刊论文  OAI收割 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024, 页码: 13 作者:  Feng, Dazhi;  Liu, Bo;  Chen, Zhiwei;  Xu, Jinyi;  Geng, Meiyu   |  收藏  |  浏览/下载：27/0  |  提交时间：2024/02/27 HPK1 inhibitor  machine learning  virtual screening  free energy perturbation  structural modification   KinomeMETA: meta-learning enhanced kinome-wide polypharmacology profiling 期刊论文  OAI收割 BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 25, 期号: 1, 页码: 15 作者:  Ren, Qun;  Qu, Ning;  Sun, Jingjing;  Zhou, Jingyi;  Liu, Jin   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/05/07 kinome profiling  kinase inhibitors  polypharmacology  deep learning  meta-learning   Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei   |  收藏  |  浏览/下载：22/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   Discovery of novel isopropanolamine inhibitors against MoTPS1 as potential fungicides with unique mechanisms 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 260, 页码: 14 作者:  Jiang, Zhiyang;  Shi, Dongmei;  Chen, Yitong;  Li, Huilin;  Wang, Jin 'e   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Rice blast  Trehalose-6-phosphate synthase  Isopropanolamine compounds  Inhibitor  Fungicidal mechanism   Discovery, Structure-Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein-Protein Interactions between AF9/ENL and AF4 or DOT1L 期刊论文  OAI收割 CANCERS, 2023, 卷号: 15, 期号: 21, 页码: 28 作者:  Li, Xin;  Wu, Xiaowei;  Nie, Shenyou;  Zhao, Jidong;  Yao, Yuan   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/19 MLL-rearranged leukemia  super elongation complexes  small-molecule inhibitor  protein-protein interaction  cancer therapeutics   Discovery of novel cGAS inhibitors based on natural flavonoids 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 14 作者:  Li, Jiameng;  Xiong, Muya;  Liu, Jiayuan;  Zhang, Fengping;  Li, Minjun   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Cyclic GMP-AMP synthase  Inhibitor  Flavonoids  Crystal structure  Virtual screening   Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 9 作者:  Lu, Shiwei;  Zhang, Feng;  Gong, Jiahao;  Huang, Jian;  Zhu, Guanghao   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/12/08 Cytochrome P450 3A4 (CYP3A4)  Inhibitors  Isoquinoline chalcones  Orally active   Discovery of a novel OGT inhibitor through high-throughput screening based on Homogeneous Time-Resolved Fluorescence (HTRF) 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 139, 页码: 12 作者:  Wu, Xinyu;  Wang, Mingchen;  Cao, Yu;  Xu, Ying;  Yang, Ziqun   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/02/27 O-GlcNAcylation  O-GlcNAc transferase  High-throughput screening  Inhibitor