中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [10]
合肥物质科学研究院 [9]
过程工程研究所 [2]
生态环境研究中心 [2]
成都山地灾害与环境研... [1]
遥感与数字地球研究所 [1]
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OAI收割 [28]
内容类型
期刊论文 [27]
会议论文 [1]
发表日期
2024 [2]
2023 [6]
2022 [1]
2020 [2]
2019 [1]
2018 [1]
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学科主题
Environmen... [1]
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浏览/检索结果:
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The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring
期刊论文
OAI收割
CELL REPORTS, 2024, 卷号: 43, 期号: 10, 页码: 23
作者:
Shen, Chunxiang
;
Zhu, Xinyi
;
Chang, Hao
;
Li, Chen
;
Hou, Min
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/11/05
Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 10
作者:
Chen, Guofeng
;
Xie, Hang
;
Liu, Jiayuan
;
Shao, Qiang
;
Li, Minjun
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/01/26
Methyl substitution
Selectivity
FABP4 inhibitor
Anti-inflammation
Metabolic stability
Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14
作者:
Liu, Jiayuan
;
Zhang, Xianglei
;
Chen, Guofeng
;
Shao, Qiang
;
Zou, Yi
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2024/01/16
Phosphodiesterase-4 (PDE4)
PDE5
Inhibitor
Drug repurposing
Crystal structure
Structure -guided optimization
Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 15
作者:
Jiang, Xiangrui
;
Su, Haixia
;
Shang, Weijuan
;
Zhou, Feng
;
Zhang, Yan
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2024/03/25
Ootheca mantidis mitigates renal fibrosis in mice by the suppression of apoptosis via increasing the gut microbe
Akkermansia
muciniphila
and modulating glutamine metabolism
期刊论文
OAI收割
BIOMEDICINE & PHARMACOTHERAPY, 2023, 卷号: 166, 页码: 15
作者:
Wang, Jue
;
Guo, Xiaozhen
;
Zou, Ziyuan
;
Yu, Minjun
;
Li, Xueling
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2023/12/08
Ootheca mantidis
Unilateral ureteral obstruction
Renal interstitial fibrosis
Apoptosis
Akkermansia muciniphila
Glutamine
Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 10, 页码: 15
作者:
Wang, Qian
;
Chen, Guofeng
;
He, Jian
;
Li, Jiameng
;
Xiong, Muya
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2023/10/17
SARS-CoV-2
papain-like protease
covalent inhibitor
co-crystal structure
in vitro assay
Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines
期刊论文
OAI收割
BIOCHEMICAL PHARMACOLOGY, 2023, 卷号: 207, 页码: 16
作者:
Gao, Jing
;
Zhou, Chen
;
Zhong, Yan
;
Shi, Li
;
Luo, Xuanyang
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2023/04/10
HSP90
ATP competitive inhibitors
Tip-based affinity selection-mass spectrometry
Dipyridamole
Cell cycle regulators
High-precision early warning system for rice cadmium accumulation risk assessment
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2023, 卷号: 859
作者:
Yan, Huili
;
Guo, Hanyao
;
Li, Ting
;
Zhang, Hezifan
;
Xu, Wenxiu
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/03/07
Genotype-to-phenotype prediction
Rice
Cd risk early warning
Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 页码: 10
作者:
Hu, Hangchen
;
Wang, Qian
;
Su, Haixia
;
Shao, Qiang
;
Zhao, Wenfeng
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/04/10
Allosteric Modulator
Cysteine 270
Drug Design
Papain-Like Protease
SARS-CoV-2
Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 4090-4106
作者:
Su, Haixia
;
Zou, Yi
;
Chen, Guofeng
;
Dou, Huixia
;
Xie, Hang
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01