机构

• 上海药物研究所 [11]

采集方式

• OAI收割 [11]

内容类型

• 期刊论文 [11]

发表日期

• 2024 [1]
• 2023 [2]
• 2022 [2]
• 2021 [1]
• 2020 [1]
• 2019 [2]
• 更多

学科主题

筛选

浏览/检索结果: 共11条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 7, 页码: 3286-3290 作者:  Zheng, Miao;  Feng, Bo;  Zhang, Yumin;  Liu, Xin;  Zhao, Na   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/08/22 Non-covalent PLpro inhibitors  Antiviral activity  Structural-based drug design  Imidazo[4,5-b]pyridine scaffold   Discovery of Polyphenolic Natural Products as SARS-CoV-2 Mpro Inhibitors for COVID-19 期刊论文  OAI收割 PHARMACEUTICALS, 2023, 卷号: 16, 期号: 2, 页码: 190 作者:  Kruger, Nadine;  Kronenberger, Thales;  Xie, Hang;  Rocha, Cheila;  Pohlmann, Stefan   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/03/27 antivirals  coronavirus  COVID-19  covalent drugs  dynamic light scattering  inhibitors  main protease  natural products   Design, synthesis and biological evaluation of KRASG12C-PROTACs 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 78, 页码: 14 作者:  Zhang, Xiaoyi;  Zhao, Tong;  Sun, Minghao;  Li, Pei;  Lai, Mengzhen   |  收藏  |  浏览/下载：27/0  |  提交时间：2023/04/10 KRASG12C  PROTAC  Covalent inhibitors  Structure-activity relationships (SARs)  Anticancer   Triazine-Based Covalent DNA-Encoded Libraries for Discovery of Covalent Inhibitors of Target Proteins 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2022, 页码: 8 作者:  Li, Linjie;  Su, Mingbo;  Lu, Weiwei;  Song, Hongzhi;  Liu, Jiaxiang   |  收藏  |  浏览/下载：30/0  |  提交时间：2022/09/30 DNA encoded library  covalent library  library design  covalent inhibitors   Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 233, 页码: 18 作者:  Cao, Yu;  Tu, Yutong;  Fu, Liping;  Yu, Qian;  Gao, Lixin   |  收藏  |  浏览/下载：50/0  |  提交时间：2022/06/15 Metabolism  Design  Proteasome inhibitors  Non-covalent  Multiple myeloma   Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794 作者:  Wu, Xiaowei;  Dai, Mengdi;  Cui, Rongrong;  Wang, Yulan;  Li, Chunpu   |  收藏  |  浏览/下载：53/0  |  提交时间：2021/05/24 Tyrosine kinase  Covalent FGFR inhibitors  Virtual screening  Pyrazolo[3,4-d] pyridazinone  Structure-activity relationships  Antitumor efficacy   Characterization of covalent binding of tyrosine kinase inhibitors to plasma proteins 期刊论文  OAI收割 DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 35, 期号: 5, 页码: 456-465 作者:  Liu, Xiaoyun;  Feng, Dan;  Zheng, Mingyue;  Cui, Yongmei;  Zhong, Dafang   |  收藏  |  浏览/下载：45/0  |  提交时间：2020/12/21 Covalent tyrosine kinase inhibitors  Covalent binding  Human serum albumin  Molecular docking  Quantitative calculations  Linear modeling  Species difference   Design, synthesis and biological study of potent and covalent HER-2 tyrosine kinase inhibitors with low cytotoxicity in vitro 期刊论文  OAI收割 CHEMICAL PAPERS, 2019, 卷号: 73, 期号: 6, 页码: 1333-1345 作者:  Jin, Shuyu;  Sun, Xiuyun;  Liu, Dan;  Xie, Hua;  Rao, Yu   |  收藏  |  浏览/下载：29/0  |  提交时间：2020/07/01 HER-2 inhibitors  4-Anilino-3-cyanoquinoline  Covalent  Anticancer activity   Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 602-614 作者:  Dong, Xiao-Wu;  Zhang, Jian-Kang;  Xu, Lei;  Che, Jin-Xin;  Cheng, Gang   |  收藏  |  浏览/下载：29/0  |  提交时间：2020/07/01 Proteasome inhibitors  Tripeptide  Covalent docking  Interaction mode   Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 126, 页码: 1056-1070 作者:  Zhuang, Rangxiao;  Gao, Lixin;  Lv, Xiaoqing;  Xi, Jianjun;  Sheng, Li   |  收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 Proteasome inhibitors  Piperazine or piperidine  Non-covalent  Peptidyl derivatives  Anti-cancer