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浏览/检索结果: 共89条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 144, 页码: 18 作者:  Zhuo, Ning;  Yun, Ying;  Zhang, Chenlu;  Guo, Shimeng;  Yin, Jianpeng   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/25 Type 2 Diabetes  TGR5 agonist  Betulinic acid  Gut-restricted  Gallbladder-filling effects  Kinetophores   Eliminating drug target interference with specific antibody or its F(ab′)2 fragment in the bridging immunogenicity assay 期刊论文  OAI收割 BIOANALYSIS, 2024, 页码: 14 作者:  Deng, Xiaojie;  Hou, Yingying;  Yuan, Wenyi;  Yang, Hongzhou;  Guo, Ruowen   |  收藏  |  浏览/下载：135/0  |  提交时间：2024/04/09 anti-drug antibody  IgE  immunogenicity  mitigation  target interference   A validated LC-MS/MS method for the quantification of bevacizumab in rat, cynomolgus monkey, and human serum 期刊论文  OAI收割 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 卷号: 235, 页码: 11 作者:  Zhou, Ainan;  Yu, Jinghua;  Wu, Yali;  Xue, Hao;  Zhong, Dafang   |  收藏  |  浏览/下载：10/0  |  提交时间：2023/10/17 Monoclonal antibody  Bevacizumab  LC-MS  MS  Surrogate peptide  Pharmacokinetics  Serum   Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E-based Antibody-Drug Conjugate for Treatment of Nectin-4-expressing Cancers 期刊论文  OAI收割 MOLECULAR CANCER THERAPEUTICS, 2023, 卷号: 22, 期号: 8, 页码: 913-925 作者:  Zhou, Wei;  Fang, Peng;  Yu, Dongan;  Ren, Hongyuan;  You, Meng   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/10/17 Bispecific antibody targeting both B7-H3 and PD-L1 exhibits superior antitumor activities 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 9 作者:  Li, Hua-ying;  Chen, Yi-li;  Deng, Xiang-nan;  Li, Huan-huan;  Tan, Jie   |  收藏  |  浏览/下载：23/0  |  提交时间：2023/10/17 cancer immunotherapy  B7-H3  PD-L1  bispecific antibodies  VHH  antibody-dependent cell-mediated cytotoxicity (ADCC)   Development, Validation and Application of a Bridging ELISA for Detection of Antibodies against GQ1001 in Cynomolgus Monkey Serum 期刊论文  OAI收割 MOLECULES, 2023, 卷号: 28, 期号: 4, 页码: 1684 作者:  Liu, Tingting;  Sun, Yajun;  Deng, Xiaojie;  Shi, Lili;  Chen, Wenyi   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/03/27 antibody-drug conjugate  immunogenicity  anti-drug antibody  bridging ELISA   AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 14 作者:  Pei, Jin-peng;  Wang, Yue;  Ma, Lan-ping;  Wang, Xin;  Liu, Liang   |  收藏  |  浏览/下载：21/0  |  提交时间：2023/04/10 AXL  NSCLC  TNBC  M2-macrophage  antibody-drug conjugate   Development of a bridging ELISA for detection of antibodies against ZV0203 in cynomolgus monkey serum 期刊论文  OAI收割 JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2023, 卷号: 119, 页码: 10 作者:  Liu, Tingting;  Tong, Yongliang;  Gao, Jinli;  Fang, Wenjing;  Wu, Junliang   |  收藏  |  浏览/下载：21/0  |  提交时间：2023/04/10 Antibody-drug conjugate  Immunogenicity  Anti-drug antibody  Bridging ELISA   PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way 期刊论文  OAI收割 JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 卷号: 10, 期号: 10, 页码: 15 作者:  Yu, Xiaolu;  Long, Yiru;  Chen, Binfan;  Tong, Yongliang;  Shan, Mengwen   |  收藏  |  浏览/下载：35/0  |  提交时间：2022/12/13 PD-L1  TLR7  nanobody-drug-conjugate  cancer immunotherapy   Development of a variant of dinutuximab with enhanced antitumor efficacy and reduced induction of neuropathic pain 期刊论文  OAI收割 FEBS OPEN BIO, 2022, 卷号: 12, 期号: 9, 页码: 1644-1656 作者:  Liu, Xin-Yuan;  Chen, Yi-Li;  Liu, Guo-Jian;  Deng, Xiang-Nan;  Cui, Yue   |  收藏  |  浏览/下载：29/0  |  提交时间：2022/09/30 ADCC  affinity maturation  antibody engineering  anti-GD2 antibodies  engineered Fc domain  humanized