中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [57]
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Development and Validation of an ADA-Tolerant Assay for Quantification of an Exatecan-Based ADC in Monkey Plasma
期刊论文
OAI收割
MOLECULES, 2024, 卷号: 29, 期号: 3, 页码: 14
作者:
Tao, Yimin
;
Lu, Wei
;
Gao, Jinli
;
Yang, Shuangshuang
;
Ruan, Chaoyi
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/03/13
antibody-drug conjugate (ADC)
bioanalysis
anti-drug antibody (ADA)
ligand binding assay (LBA)
ADA-tolerant assay
Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study
期刊论文
OAI收割
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 125, 页码: 12
作者:
Zhao, Tian-Tian
;
Hu, Hao-Jie
;
Gao, Li-Xin
;
Zhou, Yu-Bo
;
Zhu, Yun-Long
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/10/17
Protein tyrosine phosphatases inhibitors
PTP1B inhibitors
Mechanism study
Molecular dynamics
Zebrafish (Danio rerio) TR beta- and TTR-based electrochemical biosensors: Construction and application for the evaluation of thyroid-disrupting activity of bisphenols
期刊论文
OAI收割
ENVIRONMENTAL POLLUTION, 2023, 卷号: 330, 页码: 9
作者:
Li, Yuejiao
;
Zhang, Zhenzhong
;
Wang, Jun
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/07
Thyroid-disrupting chemicals
Thyroid hormone receptor beta
Transthyretin
In vitro screening Assay
Electrochemical biosensor
Design, Synthesis and Bioactivity of [3.3.3]Propellane-Based Voltage-Gated Calcium Channel alpha 2 delta Subunit Ligands
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2023, 卷号: 43, 期号: 6, 页码: 2226-2238
作者:
He Jinyan
;
Tian Fuyun
;
Wu Qingqing
;
Zheng Yueming
;
Chen Yuting
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2023/10/17
propellane
voltage-gated calcium channel
alpha 2 delta subunit
synthesis
bioactivity
structure-activity relationship
Simulating androgen receptor selection in designer yeast
期刊论文
OAI收割
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022, 卷号: 7
作者:
Zhang, Haoran
;
Zhang, Lu
;
Xu, Yipeng
;
Chen, Shaoyong
;
Ma, Zhenyi
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/12/23
Androgen receptor mutations
Androgen receptor antagonists
Prostate cancer
Saccharomyces cerevisiae
Current Analytical Strategies for Antibody-Drug Conjugates in Biomatrices
期刊论文
OAI收割
MOLECULES, 2022, 卷号: 27, 期号: 19, 页码: 17
作者:
Qin, Qiuping
;
Gong, Likun
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/11/11
ADC
antibody
payload
LBA
LC-MS
bioanalysis
immunogenicity
interference
Comparative study of the immunomodulatory effects of different fucoidans from Saccharina japonica mediated by scavenger receptors on RAW 264.7 macrophages
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 卷号: 215, 页码: 253-261
作者:
Cui, Meiyu
;
Li, Xiaohong
;
Geng, Lihua
;
Wu, Ning
;
Wang, Jing
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/08/17
Fucoidan
Saccharina japonica
Scavenger receptor
Macrophage
SR-A
CD36
LOX-1
Immunomodulatory
Antinociceptive activities and mechanism of action of Cepharanthine
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 卷号: 614, 页码: 219-224
作者:
Wei, Xiang-Yan
;
Long, Jian-Dong
;
Chai, Jing-Rui
;
Chen, Jing
;
Gao, Jian-Ping
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/08/16
Cepharanthine
Antinociception
mu opioid receptors
Constipation
Matrix Thermal Shift Assay for Fast Construction of Multidimensional Ligand-Target Space
期刊论文
OAI收割
ANALYTICAL CHEMISTRY, 2022, 卷号: 94, 期号: 17, 页码: 6482-6490
作者:
Ruan, Chengfei
;
Wang, Yan
;
Zhang, Xiaolei
;
Lyu, Jiawen
;
Zhang, Na
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2022/11/08
DRUG
STABILIZATION
IRON
Development and validation of a ligand-binding assay for quantification of the F(ab')(2) antivenom of Daboia russelii siamensis in human serum and its application to a phase I clinical study
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2022, 卷号: 212, 页码: 8
作者:
Gui, Yuzhou
;
Yu, Chengyin
;
Zhou, Jiaye
;
Xin, Liang
;
Chen, Ze
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/06/15
F(ab')(2) antivenom
Daboia russelii siamensis
Ligand-binding assay
Method validation
Clinical trial