中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [373]
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OAI收割 [373]
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期刊论文 [370]
会议论文 [3]
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2024 [7]
2023 [14]
2022 [21]
2021 [24]
2020 [32]
2019 [15]
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专题:上海药物研究所
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Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 144, 页码: 18
作者:
Zhuo, Ning
;
Yun, Ying
;
Zhang, Chenlu
;
Guo, Shimeng
;
Yin, Jianpeng
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/25
Type 2 Diabetes
TGR5 agonist
Betulinic acid
Gut-restricted
Gallbladder-filling effects
Kinetophores
Safety, pharmacokinetics, and food effect of sudapyridine (WX-081), a novel anti-tuberculosis candidate in healthy Chinese subjects
期刊论文
OAI收割
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2024, 卷号: 17, 期号: 2, 页码: 10
作者:
Yu, Chengyin
;
Qian, Hongjie
;
Wu, Qingqing
;
Zou, Yang
;
Ding, Qicheng
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/03/06
Development and Validation of an ADA-Tolerant Assay for Quantification of an Exatecan-Based ADC in Monkey Plasma
期刊论文
OAI收割
MOLECULES, 2024, 卷号: 29, 期号: 3, 页码: 14
作者:
Tao, Yimin
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/03/13
antibody-drug conjugate (ADC)
bioanalysis
anti-drug antibody (ADA)
ligand binding assay (LBA)
ADA-tolerant assay
Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 16
作者:
Cheng, Chen
;
Ren, Chao
;
Li, Mu-zi
;
Liu, Yi-hui
;
Yao, Ren-qi
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/02/27
Traditional Chinese medicine
XueBiJing
sepsis
mortality
pharmacokinetic compatibility
polypharmacology
A NIR-II Photoacoustic/NIR-IIa Fluorescent Probe for Targeted Imaging of Glioma under NIR-II Excitation
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 3, 页码: 1861-1871
作者:
Lyu, Shuxin
;
Lu, Siyu
;
Gui, Conghao
;
Guo, Chunyan
;
Han, Juanjuan
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/13
Sevoflurane Alters Serum Metabolites in Elders and Aging Mice and Increases Inflammation in Hippocampus
期刊论文
OAI收割
JOURNAL OF INFLAMMATION RESEARCH, 2024, 卷号: 17, 页码: 1241-1253
作者:
Wang, Tingting
;
Wu, Xia
;
Zhao, Xiaoli
;
Li, Jiaqi
;
Yu, Jian
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/04/09
sevoflurane
hippocampus
neuroinflammation
RNA-seq
metabolomics
isatin
Development and validation of a sensitive liquid chromatography-tandem mass spectrometry method for the assay of 12 substances in rat plasma and its application to rat pharmacokinetics of
Epimedium
and
Psoraleae Fructus
herb pair after oral administration
期刊论文
OAI收割
JOURNAL OF SEPARATION SCIENCE, 2024, 卷号: 47, 期号: 1, 页码: 17
作者:
Wang, Linwei
;
Yin, Xiaoying
;
Liu, Huan
;
Wang, Yangyang
;
Li, Zhixiong
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/02/27
compatibility behaviors
Epimedium
LC-MS/MS
pharmacokinetics
Psoraleae Fructus
Safety, tolerability and pharmacokinetics of forsythin in healthy subjects: a double-blinded, placebo-controlled single-dose and multiple-dose escalation and food effect study
期刊论文
OAI收割
ANNALS OF MEDICINE, 2023, 卷号: 55, 期号: 2, 页码: 9
作者:
Li, Cuiyun
;
Wu, Min
;
Zhang, Hong
;
Zhu, Xiaoxue
;
Fu, Li
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/01/16
Forsythin
pharmacokinetics
safety
tolerability
food effect
A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9
作者:
Yang, Xin-Mei
;
Yang, Yang
;
Yao, Bu-Fan
;
Ye, Pan-Pan
;
Xu, Yan
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/12/11
COVID-19
Simnotrelvir
Safety
Pharmacokinetics
Healthy subjects
Glutamine Production by Glul Promotes Thermogenic Adipocyte Differentiation Through Prdm9-Mediated H3K4me3 and Transcriptional Reprogramming
期刊论文
OAI收割
DIABETES, 2023, 卷号: 72, 期号: 11, 页码: 24
作者:
Pan, Xiaowen
;
Ye, Lingxia
;
Guo, Xiaozhen
;
Wang, Weihua
;
Zhang, Ziyin
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/25