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浏览/检索结果: 共94条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Hemodynamic and Pharmacokinetic Interactions of TPN171 with Alcohol in Healthy Male Subjects 期刊论文  OAI收割 CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2025, 卷号: 18, 期号: 2, 页码: 8 作者:  Cheng, Jie;  Qian, Hongjie;  Wang, Yu;  Liang, Liyu;  Xu, Wenjing   |  收藏  |  浏览/下载：4/0  |  提交时间：2025/04/01 alcohol  healthy subjects  hemodynamics  PDE5 inhibitor  pharmacokinetics  TPN171   Two new limonoid glycosides from the seeds of Citrus Limon and their PDE4D inhibitory activities 期刊论文  OAI收割 NATURAL PRODUCT RESEARCH, 2024, 页码: 7 作者:  Fu, Yifan   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/08/20 Citrus Limon  limonoid glycosides  PDE4D inhibitory activity   Ent-labdane-type diterpene glycosides obtained from Rubus chingii Hu and their inhibitory effects on PDE5A activity 期刊论文  OAI收割 FITOTERAPIA, 2024, 卷号: 173, 页码: 14 作者:  Yu, Jun-dong;  Wang, Jing-Yi;  Liu, Jia-yuan;  Xu, Ye-chun;  Zhang, Xue   |  收藏  |  浏览/下载：25/0  |  提交时间：2024/02/27 diterpene glycosides  Rubus Chingii Hu  PDE5A inhibitory activity  ent-labdane   H∞ deployment of nonlinear multi-agent systems with Markov switching topologies over a finite-time interval based on T-S fuzzy PDE control 期刊论文  OAI收割 AIMS MATHEMATICS, 2024, 卷号: 9, 期号: 2, 页码: 4076-4097 作者:  Wei, Hongbo;  Cui, Xuerong;  Zhang, Yucheng;  Zhang, Jingyao   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/12/06 nonlinear MASs  H infinity deployment  finite-time interval  fuzzy PDE-based control  Markov switching topologies   Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei;  Chen, Guofeng;  Shao, Qiang;  Zou, Yi   |  收藏  |  浏览/下载：32/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   Pharmacokinetics,mass balance,and metabolism of 14C TPN171,a novel PDE5 inhibitor,in humans for the treatment of pulmonary arterial hypertension 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 1, 页码: 221 作者:  He Yifei;  Liu Yin;  Yu Jinghua;  Cheng Huan;  Odilov Abdullajon   |  收藏  |  浏览/下载：23/0  |  提交时间：2023/05/22 TPN171  14CTPN171  PDE5 inhibitor  pulmonary arterial hypertension  healthy volunteers  pharmacokinetics  metabolite identification  mass balance   Pharmacokinetics, mass balance, and metabolism of [C-14]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13 作者:  He, Yi-fei;  Liu, Yin;  Yu, Jing-hua;  Cheng, Huan;  Odilov, Abdullajon   |  收藏  |  浏览/下载：42/0  |  提交时间：2022/08/16 TPN171  [C-14]TPN171  PDE5 inhibitor  pulmonary arterial hypertension  healthy volunteers  pharmacokinetics  metabolite identification  mass balance   A local integral-generalized finite difference method with mesh-meshless duality and its application 期刊论文  OAI收割 ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS, 2022, 卷号: 139, 页码: 14 作者:  Bai, Bing;  Ci, Huiling;  Lei, Hongwu;  Cui, Yinxiang   |  收藏  |  浏览/下载：28/0  |  提交时间：2023/08/02 Mesh-meshless duality  Numerical method  Integral-generalized finite difference (IGFD)  Generalized finite difference (GFD)  Partial differential equation (PDE)   A Nitsche Hybrid Multiscale Method with Non-matching Grids 期刊论文  OAI收割 JOURNAL OF SCIENTIFIC COMPUTING, 2022, 卷号: 91, 期号: 2, 页码: 28 作者:  Ming, Pingbing;  Song, Siqi   |  收藏  |  浏览/下载：18/0  |  提交时间：2022/04/29 Multiscale PDE  Hybrid method  Nitsche variational formulation  Non-matching grid   Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 1, 页码: 228-245 作者:  Li, Heng;  Zhang, Yao;  Liu, Moting;  Fan, Chen;  Feng, Chunlan   |  收藏  |  浏览/下载：35/0  |  提交时间：2022/06/15 Ulcerative colitis  Mucosal homeostasis  Gut microbiota  Epithelial barrier  PDE4