机构

• 上海药物研究所 [561]

采集方式

• OAI收割 [561]

内容类型

• 期刊论文 [561]

发表日期

• 2023 [34]
• 2022 [31]
• 2021 [25]
• 2020 [19]
• 2019 [25]
• 2018 [29]
• 更多

学科主题

• Chemistry [20]
• Biochemis... [18]
• Pharmacol... [10]
• Biophysics [5]
• Biotechnol... [2]
• Computer S... [2]
• 更多

筛选

浏览/检索结果: 共561条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Eleven highly oxygenated and anti-inflammatory guaian-8,12-olides from Hedyosmum orientale 期刊论文  OAI收割 TETRAHEDRON, 2024, 卷号: 152, 页码: 8 作者:  Fan, Yao-Yue;  Zhang, Xin-Ru;  Zheng, Cheng-Yu;  Li, Ying;  Yue, Jian-Min   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/25 Hedyosmum orientale  Natural products  Guaian-8,12-olide  Structure elucidation  Anti-inflammatory activity   Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17 作者:  Lan, Yaohan;  Peng, Xia;  Ji, Yinchun;  Su, Yi;  Duan, Wenhu   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/02/27 AXL inhibitor  In vivo antitumor efficacy  6-Naphthyridin-4-one derivatives  Scaffold hopping  Structure-based drug design   Platanosides from Platanus x acerifolia: New molecules, SAR, and target validation of a strong lead for drug-resistant bacterial infections and the associated sepsis 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 9 作者:  Wu, Xi-Ying;  Zhao, Ze-Yu;  Osman, Ezzat E. A.;  Wang, Xiao-Juan;  Choo, Yeun-Mun   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/06 Platanus x acerifolia  Platanosides  Molecular ion networking (MoIN)  Antibacterial  Staphylococcus aureus  Enterococcus faecium  Structure -activity relationship (SAR)  Molecular docking  Target validation   Synthesis and Biological Evaluation of β-Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP) 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 15, 期号: 2, 页码: 270-279 作者:  Zhou, Chenmao;  Hao, Xinyue;  Chen, Zhengyang;  Zhang, Runze;  Zhou, Qian   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/03/13 Speckle-type POZ protein (SPOP)  SPOP inhibitors  Clear cell renal cell carcinoma (ccRCC)  Structure-activityrelationship (SAR)   Benzothiozinone derivatives with anti-tubercular Activity-Further side chain investigation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 11 作者:  Wu, Xiaomei;  Wang, Wenxin;  Stelitano, Giovanni;  Riabova, Olga;  Wang, Bin   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/01/26 Anti -tubercular activity  DprE1 inhibitor  Benzothiazinone derivatives  Structure activity relationship   Structure-based development of potent and selective type-II kinase inhibitors of RIPK1 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334 作者:  Qin, Ying;  Li, Dekang;  Qi, Chunting;  Xiang, Huaijiang;  Meng, Huyan   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/03/06 RIPK1  Necroptosis  Type-II kinase inhibitors  Rational design  Lead optimization  Structure-activity relationship  Anti-inflammation  Preclinical drug discovery   The claim of primacy of human gut Bacteroides ovatus in dietary cellobiose degradation 期刊论文  OAI收割 GUT MICROBES, 2023, 卷号: 15, 期号: 1, 页码: 18 作者:  Li, Meixia;  Wang, Yeqing;  Guo, Ciliang;  Wang, Sheng;  Zheng, Liangzhen   |  收藏  |  浏览/下载：63/0  |  提交时间：2023/10/17 Human gut microbiota  cellobiose  bacteroide ovatus  cellulase  structure   Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei;  Chen, Guofeng;  Shao, Qiang;  Zou, Yi   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   Synthesis, evaluation and molecular dynamics study of human toll-like receptor 2/6 specific monoacyl lipopeptides as candidate immunostimulants 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 141, 页码: 17 作者:  Zhu, Yueyue;  Liu, Bo;  Chen, Zonglong;  Wang, Xianyang;  Wang, Yujie   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Toll -like receptor 2/6 agonists  PamCS  Structure-activity relationship  Lipopeptide  Immunostimulants   Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933 作者:  Fang, Feifei;  Dai, Yang;  Wang, Hao;  Ji, Yinchun;  Liang, Xuewu   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/01/26 derivatives  Antitumor drug development  Potential AXL inhibitor  Antitumor activity  Structure-based drug design  Fused-pyrazolone carboxamide