机构

• 上海药物研究所 [67]

采集方式

• OAI收割 [67]

内容类型

• 期刊论文 [67]

发表日期

• 2023 [67]

学科主题

筛选

浏览/检索结果: 共67条，第1-10条 帮助 限定条件 发表日期：2023    内容类型：期刊论文    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序题名升序题名降序作者升序作者降序发表日期升序发表日期降序 Recognition of methamphetamine and other amines by trace amine receptor TAAR1 期刊论文  OAI收割 NATURE, 2023, 卷号: 624, 期号: 7992, 页码: 663-+ 作者:  Liu, Heng;  Zheng, You;  Wang, Yue;  Wang, Yumeng;  He, Xinheng   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/03/25 Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 18 作者:  Zhang, Jingyu;  Duan, Haiting;  Gui, Renzhao;  Wu, Mingfei;  Shen, Liteng   |  收藏  |  浏览/下载：19/0  |  提交时间：2023/12/19 Acute myeloid leukemia  Bromodomain-containing protein 9  Proteolysis-targeting chimera  Orally bioavailable  Docking   Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 96, 页码: 12 作者:  Song, Zhaoxiang;  Lu, Dan;  Sun, Jun;  Ye, Yangliang;  Fang, Jiahui   |  收藏  |  浏览/下载：31/0  |  提交时间：2024/01/16 GPR35  IBD  Lodoxamide   Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei;  Chen, Guofeng;  Shao, Qiang;  Zou, Yi   |  收藏  |  浏览/下载：22/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   Discovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1 期刊论文  OAI收割 RSC MEDICINAL CHEMISTRY, 2023, 页码: 14 作者:  Deng, Minjie;  Gao, Yue;  Wang, Peipei;  Du, Wenjing;  Xu, Gaoya   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/02/19 Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764 作者:  Liu, Yingqiang;  Zhan, Zhengsheng;  Kang, Zhuang;  Li, Mengyuan;  Lv, Yongcong   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/01/26 Small molecule inhibitor  Tumor microenvironment  Immune-checkpoint  immune-deficient mouse models  including temozolomide (TMZ) insensitive tumors. Notably   Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933 作者:  Fang, Feifei;  Dai, Yang;  Wang, Hao;  Ji, Yinchun;  Liang, Xuewu   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/01/26 derivatives  Antitumor drug development  Potential AXL inhibitor  Antitumor activity  Structure-based drug design  Fused-pyrazolone carboxamide   Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2 期刊论文  OAI收割 CELL REPORTS, 2023, 卷号: 42, 期号: 11, 页码: 19 作者:  Zhu, Shengnan;  Yuan, Qingning;  Li, Xinzhu;  He, Xinheng;  Shen, Shiyi   |  收藏  |  浏览/下载：193/0  |  提交时间：2024/01/16 different ligands  recognition  ligand selectivity  receptor   An ultra-compact promoter drives widespread neuronal expression in mouse and monkey brains 期刊论文  OAI收割 CELL REPORTS, 2023, 卷号: 42, 期号: 11, 页码: 21 作者:  Wang, Jingyi;  Lin, Jianbang;  Chen, Yefei;  Liu, Jing;  Zheng, Qiongping   |  收藏  |  浏览/下载：37/0  |  提交时间：2024/01/16 The new direction of drug development: Degradation of undruggable targets through targeting chimera technology 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2023, 页码: 54 作者:  Liang, Xuewu;  Ren, Hairu;  Han, Fengyang;  Liang, Renwen;  Zhao, Jiayan   |  收藏  |  浏览/下载：26/0  |  提交时间：2024/01/16 chimeric design  degradation System  PROTAC  targeted degradation technology  undruggable targets