机构

• 上海药物研究所 [91]
• 西北高原生物研究所 [2]
• 合肥物质科学研究院 [2]
• 成都山地灾害与环境研... [1]
• 地质与地球物理研究所 [1]
• 计算技术研究所 [1]
• 更多

采集方式

• OAI收割 [101]

内容类型

• 期刊论文 [101]

发表日期

• 2023 [101]

学科主题

筛选

浏览/检索结果: 共101条，第1-10条 帮助 限定条件 发表日期：2023     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Targeting ST8SIA6-AS1 counteracts KRASG12C inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling 期刊论文  OAI收割 EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2023, 卷号: 12, 期号: 1, 页码: 22 作者:  Wang, Yafang;  Yao, Mingyue;  Li, Cheng;  Yang, Kexin;  Qin, Xiaolong   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/01/26 KRAS(G12C)  c-Myc  PLK1  LncRNA  ST8SIA6-AS1  Drug resistance   Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 18 作者:  Zhang, Jingyu;  Duan, Haiting;  Gui, Renzhao;  Wu, Mingfei;  Shen, Liteng   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/12/19 Acute myeloid leukemia  Bromodomain-containing protein 9  Proteolysis-targeting chimera  Orally bioavailable  Docking   Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei;  Chen, Guofeng;  Shao, Qiang;  Zou, Yi   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   Discovery of Dual Function Agents That Exhibit Anticancer Activity via Catastrophic Nicotinamide Adenine Dinucleotide Depletion 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16694-16703 作者:  Fu, Yixian;  Huang, Yahui;  Zhou, Chenchen;  Li, Xinge;  Dong, Guoqiang   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/01/26 Discovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1 期刊论文  OAI收割 RSC MEDICINAL CHEMISTRY, 2023, 页码: 14 作者:  Deng, Minjie;  Gao, Yue;  Wang, Peipei;  Du, Wenjing;  Xu, Gaoya   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/02/19 Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025 作者:  Cheng, Jing;  Yan, Ziqin;  Jiang, Kailong;  Liu, Chen;  Xu, Dehua   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/02/19 From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：28/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study 期刊论文  OAI收割 JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 125, 页码: 12 作者:  Zhao, Tian-Tian;  Hu, Hao-Jie;  Gao, Li-Xin;  Zhou, Yu-Bo;  Zhu, Yun-Long   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/10/17 Protein tyrosine phosphatases inhibitors  PTP1B inhibitors  Mechanism study  Molecular dynamics   Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933 作者:  Fang, Feifei;  Dai, Yang;  Wang, Hao;  Ji, Yinchun;  Liang, Xuewu   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/01/26 derivatives  Antitumor drug development  Potential AXL inhibitor  Antitumor activity  Structure-based drug design  Fused-pyrazolone carboxamide   Glimepiride, a novel soluble epoxide hydrolase inhibitor, protects against heart failure via increasing epoxyeicosatrienoic acids 期刊论文  OAI收割 JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2023, 卷号: 185, 页码: 13-25 作者:  Zhao, Chengcheng;  Jiang, Xiangrui;  Peng, Liyuan;  Zhang, Yan;  Li, Huihui   |  收藏  |  浏览/下载：26/0  |  提交时间：2024/01/16 Heart failure  Hypertrophy  Epoxyeicosatrienoic acids  Soluble epoxide hydrolase